Justin A. Spanier
University of Minnesota
31 Papers
52 Citations
Justin A. Spanier is an academic researcher from University of Minnesota. The author has contributed to research in topics: T cell & Biology. The author has an hindex of 16, co-authored 25 publications. Previous affiliations of Justin A. Spanier include University of Wisconsin-Madison.
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Papers
Thymic regulatory T cells arise via two distinct developmental programs
David L. Owen,Shawn A. Mahmud,Louisa E. Sjaastad,Jason B. Williams,Justin A. Spanier,Dimitre R. Simeonov,Roland Ruscher,Weishan Huang,Irina Proekt,Corey N. Miller,Can Hekim,Jonathan C. Jeschke,Praful Aggarwal,Ulrich Broeckel,Rebecca S. LaRue,Christine Henzler,Maria-Luisa Alegre,Mark S. Anderson,Avery August,Alexander Marson,Ye Zheng,Calvin B. Williams,Michael A. Farrar +22 more
TL;DR: It is shown that thymic Treg cells are generated through two distinct developmental programs that are both required for a comprehensive Treg cell repertoire capable of establishing immunotolerance.
T cell receptor cross-reactivity between similar foreign and self peptides influences naive cell population size and autoimmunity.
Ryan W. Nelson,Daniel Beisang,Noah J. Tubo,Thamotharampillai Dileepan,Darin L. Wiesner,Kirsten Nielsen,Marcel Wüthrich,Bruce S. Klein,Dmitri I. Kotov,Justin A. Spanier,Brian T. Fife,James J. Moon,Marc K. Jenkins +12 more
TL;DR: It is found that nonamer peptides that bind to the same MHCII molecule only need to share five amino acids to cross-react on the same TCR, which can reduce the size of certain foreign peptide-specific T cell populations and might allow Tcell populations specific for tissue-restricted self peptides to cause autoimmunity after infection.
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Estrogen Controls Vitamin D3-Mediated Resistance to Experimental Autoimmune Encephalomyelitis by Controlling Vitamin D3 Metabolism and Receptor Expression
TL;DR: It is found that vitamin D3 inhibited experimental autoimmune encephalomyelitis (EAE) in intact female mice, but not in ovariectomized females or males, supporting the hypothesis that the sunlight-dependent hormone 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) is a natural inhibitor of autoimmune T cell responses in MS.
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Interferon-gamma drives programmed death-ligand 1 expression on islet β cells to limit T cell function during autoimmune diabetes
Kevin C. Osum,Adam L. Burrack,Tijana Martinov,Nathanael L. Sahli,Jason S. Mitchell,Christopher G. Tucker,Kristen E. Pauken,Klearchos K. Papas,Balamurugan N. Appakalai,Justin A. Spanier,Brian T. Fife +10 more
TL;DR: It is suggested that insulin-producing β cells respond to pancreatic inflammation and IFN-γ production by upregulating PD-L1 expression to limit self-reactive T cells.
Vitamin D3 alters microglia immune activation by an IL-10 dependent SOCS3 mechanism
TL;DR: Vitamin D3 increases the expression of IL-10 creating a feedback loop via SOCS3 that downregulates the pro-inflammatory immune response by activated microglia which would likewise prevent immune mediated damage in the CNS.
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