Juro Sakai
University of Tokyo
114 Papers
437 Citations
Juro Sakai is an academic researcher from University of Tokyo. The author has contributed to research in topics: Biology & Receptor. The author has an hindex of 52, co-authored 107 publications. Previous affiliations of Juro Sakai include Tohoku University & University of Fukui.
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Papers
A neuropeptide ligand of the G protein-coupled receptor GPR103 regulates feeding, behavioral arousal, and blood pressure in mice
Shinobu Takayasu,Takeshi Sakurai,Satoshi Iwasaki,Hitoshi Teranishi,Akihiro Yamanaka,S. Clay Williams,Haruhisa Iguchi,Yuka Imamura Kawasawa,Yukio Ikeda,Iori Sakakibara,Kousaku Ohno,Ryoichi X. Ioka,Saori Murakami,Naoshi Dohmae,Jian Xie,Toshihiro Suda,Toshiyuki Motoike,Takashi Ohuchi,Masashi Yanagisawa,Juro Sakai +19 more
TL;DR: The findings suggest that QRFP and GPR103A/B may regulate diverse neuroendocrine and behavioral functions and implicate this neuropeptide system in metabolic syndrome.
Direct evidence for pitavastatin induced chromatin structure change in the KLF4 gene in endothelial cells.
Takashi Maejima,Tsuyoshi Inoue,Yasuharu Kanki,Takahide Kohro,Guoliang Li,Yoshihiro Ohta,Hiroshi Kimura,Mika Kobayashi,Akashi Taguchi,Shuichi Tsutsumi,Hiroko Iwanari,Shogo Yamamoto,Hirofumi Aruga,Shoulian Dong,Junko F Stevens,Huay Mei Poh,Kazuki Yamamoto,Takeshi Kawamura,Imari Mimura,Jun-ichi Suehiro,Akira Sugiyama,Kiyomi Kaneki,Haruki Shibata,Yasunobu Yoshinaka,Takeshi Doi,Akimune Asanuma,Sohei Tanabe,Toshiya Tanaka,Takashi Minami,Takao Hamakubo,Juro Sakai,Naohito Nozaki,Hiroyuki Aburatani,Masaomi Nangaku,Xiaoan Ruan,Hideyuki Tanabe,Yijun Ruan,Sigeo Ihara,Akira Endo,Tatsuhiko Kodama,Youichiro Wada +40 more
TL;DR: In this paper, the authors performed microarray analyses of human umbilical vein endothelial cells (HUVECs) treated with pitavastatin, and KLF4 was determined to be the most highly induced gene.
A Krüppel-like factor KLF15 Contributes Fasting-induced Transcriptional Activation of Mitochondrial Acetyl-CoA Synthetase Gene AceCS2
Joji Yamamoto,Yukio Ikeda,Haruhisa Iguchi,Takahiro Fujino,Toshiya Tanaka,Hiroshi Asaba,Satoshi Iwasaki,Ryoichi X. Ioka,Izumi W. Kaneko,Kenta Magoori,Sadao Takahashi,Toshiyuki Mori,Hiroshi Sakaue,Tatsuhiko Kodama,Masashi Yanagisawa,Tokuo T. Yamamoto,Sadayoshi Ito,Juro Sakai +17 more
TL;DR: It is shown that the combination of KLF15 and Sp1 resulted in a synergistic activation of the AceCS2 promoter, and Krüppel-like factor 15 (KLF15) plays a key role in the trans-activation of the ACECS2 gene.
Pemafibrate, a selective PPARα modulator, prevents non-alcoholic steatohepatitis development without reducing the hepatic triglyceride content
Yusuke Sasaki,Masato Asahiyama,Toshiya Tanaka,Shogo Yamamoto,Kentaro Murakami,Wakana Kamiya,Yoshihiro Matsumura,Tsuyoshi Osawa,Motonobu Anai,Jean Charles Fruchart,Hiroyuki Aburatani,Juro Sakai,Juro Sakai,Tatsuhiko Kodama +13 more
TL;DR: It is found that pemafibrate improves F4/80-positive macrophage accumulation, ballooning degeneration of hepatocytes, and the non-alcoholic fatty liver disease (NAFLD) activity score without affecting triglyceride (TG) accumulation in the liver of a mouse model of NASH.
Structure, chromosome location, and expression of the human very low density lipoprotein receptor gene.
Juro Sakai,Atsushi Hoshino,Sadao Takahashi,Yukio Miura,Hirofumi Ishii,Hiroyuki Suzuki,Yutaka Kawarabayasi,Tokuo Yamamoto +7 more
TL;DR: Although the 5'-flanking region of the VLDL receptor gene contains two copies of a sterol regulatory element-1 like sequence, the levels of mRNA for the receptor in THP-1 human monocytic leukemia cells were unchanged by sterols.