Junyu Wu
Sun Yat-sen University
6 Papers
7 Citations
Junyu Wu is an academic researcher from Sun Yat-sen University. The author has contributed to research in topics: PTEN & RNase P. The author has an hindex of 2, co-authored 6 publications.
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Papers
A novel selective autophagy receptor, CCDC50, delivers K63 polyubiquitination-activated RIG-I/MDA5 for degradation during viral infection.
Panpan Hou,Kongxiang Yang,Penghui Jia,Lan Liu,Yuxin Lin,Zibo Li,Jun Li,Shuliang Chen,Shuting Guo,Ji’An A. Pan,Junyu Wu,Hong Peng,Weijie Zeng,Chunmei Li,Yingfang Liu,Deyin Guo +15 more
TL;DR: In mouse models with RNA virus infection, CCDC50 deficiency reduces the autophagic degradation of RIG-I/MDA5 and promotes type I IFN responses, resulting in enhanced viral resistance and improved survival rates, revealing a new link between autophagy and antiviral innate immune responses.
Non-Structural Protein 5 of Zika Virus Interacts with p53 in Human Neural Progenitor Cells and Induces p53-Mediated Apoptosis
Ping Li,Hualian Jiang,Hong Peng,Wei-jie Zeng,Yongheng Zhong,Miao He,Luyang Xie,Junhai Chen,Deyin Guo,Junyu Wu,Chunmei Li +10 more
TL;DR: In this article, the effects of ZIKV-encoded proteins in the activation of p53 signaling pathway were investigated, and it was found that the nonstructural protein 5 (NS5) of zika virus most significantly activated the transcription of the p53 target genes.
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Meta-Transcriptomic Analysis Reveals the Virome and Viral Genomic Evolution of Medically Important Mites.
Liping Guo,Xiaoyu Lu,Xue Liu,Ping Li,Junyu Wu,Fan Xing,Hong Peng,Xiaojun Xiao,Mang Shi,Zhigang Liu,Xiao Dong Li,Deyin Guo +11 more
TL;DR: A total transcriptomics approach was used to characterize and compare the complete RNA virome within mites that are relevant to human health and diseases, and revealed a large diversity, a high abundance, and a flexible genomic evolution for these viruses.