Junying Yu
University of Wisconsin-Madison
33 Papers
68 Citations
Junying Yu is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Induced pluripotent stem cell & Embryonic stem cell. The author has an hindex of 24, co-authored 31 publications. Previous affiliations of Junying Yu include Wisconsin Alumni Research Foundation & Morgridge Institute for Research.
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Papers
Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells
Junying Yu,Maxim A. Vodyanik,Kim Smuga-Otto,Jessica Antosiewicz-Bourget,Jennifer L. Frane,Shulan Tian,Jeff Nie,Gudrun A. Jonsdottir,Victor Ruotti,Ron Stewart,Igor I. Slukvin,James A. Thomson +11 more
TL;DR: This article showed that OCT4, SOX2, NANOG, and LIN28 factors are sufficient to reprogram human somatic cells to pluripotent stem cells that exhibit the essential characteristics of embryonic stem (ES) cells.
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Human Induced Pluripotent Stem Cells Free of Vector and Transgene Sequences
Junying Yu,Junying Yu,Kejin Hu,Kim Smuga-Otto,Kim Smuga-Otto,Shulan Tian,Shulan Tian,Ron Stewart,Ron Stewart,Igor I. Slukvin,James A. Thomson +10 more
TL;DR: Results demonstrate that reprograming human somatic cells does not require genomic integration or the continued presence of exogenous reprogramming factors and removes one obstacle to the clinical application of human iPS cells.
Induced pluripotent stem cells from a spinal muscular atrophy patient
Allison D. Ebert,Junying Yu,Ferrill F. Rose,Virginia B. Mattis,Christian L. Lorson,James A. Thomson,Clive N. Svendsen +6 more
TL;DR: This is the first study to show that human induced pluripotent stem cells can be used to model the specific pathology seen in a genetically inherited disease and represents a promising resource to study disease mechanisms, screen new drug compounds and develop new therapies.
Somatic coding mutations in human induced pluripotent stem cells
Athurva Gore,Zhe Li,Ho Lim Fung,Jessica E. Young,Suneet Agarwal,Jessica Antosiewicz-Bourget,Isabel Canto,Alessandra Giorgetti,Mason A. Israel,Evangelos Kiskinis,Je-Hyuk Lee,Yuin-Han Loh,Philip D. Manos,Nuria Montserrat,Athanasia D. Panopoulos,Sergio Ruiz,Melissa L. Wilbert,Junying Yu,Ewen F. Kirkness,Juan Carlos Izpisua Belmonte,Derrick J. Rossi,James A. Thomson,Kevin Eggan,George Q. Daley,Lawrence S.B. Goldstein,Kun Zhang +25 more
TL;DR: It is shown that 22 human induced pluripotent stem (hiPS) cell lines reprogrammed using five different methods each contained an average of five protein-coding point mutations in the regions sampled, and that hiPS cells acquire genetic modifications in addition to epigenetic modifications.
Neural differentiation of human induced pluripotent stem cells follows developmental principles but with variable potency
Baoyang Hu,Jason P. Weick,Junying Yu,Li Xiang Ma,Xiaoqing Zhang,James A. Thomson,Su-Chun Zhang +6 more
TL;DR: It is shown that human iPSCs use the same transcriptional network to generate neuroepithelia and functionally appropriate neuronal types over the same developmental time course as hESCs in response to the same set of morphogens; however, they do it with significantly reduced efficiency and increased variability.
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