Junyi Wang

TL;DR: In this article , a barcode sequencing of a eukaryotic genome-wide deletion library revealed that histone modifications, especially histone acetylation associated with the NuA4 histoneacetyltransferase complex, were involved in the anti-proliferation actions of celastrol.

TL;DR: The protein lysine methyltransferase SET7/9 adopts two structurally distinct TSs, a nearly symmetric SN2 and an extremely early SN2, for H3K4 and p53K372 methylation, respectively, which are different from those previously revealed for other PKMTs.

TL;DR: It is demonstrated that glycyrrhizin, the main active ingredient of GlycyRrhizae Radix et Rhizoma, prevents the coronavirus from entering cells by targeting angiotensin-converting enzyme 2 (ACE2).

TL;DR: An automated machine learning approach is used to reveal slow conformational motions and thus distinct conformational states of SETD8, and the resulting models provide unprecedented mechanistic insight into how protein dynamics plays a role in SAM binding and thus catalysis.