Junya Arima
14 Papers
Junya Arima is an academic researcher. The author has contributed to research in topics: Downregulation and upregulation & microRNA. The author has an hindex of 1, co-authored 2 publications.
Chat about Author
Papers
Exosomal microRNA-1 and MYO15A as a target for therapy and diagnosis in renal cell carcinoma.
Hirofumi Yoshino,Shuichi Tatarano,M. Tamai,Masafumi Tsuruda,Sayaka Iizasa,Junya Arima,I. Kawakami,W. Fukumoto,Ichiro Kawahara,Li Gang,Takashi Sakaguchi,Satoru Inoguchi,Yasutoshi Yamada,Hideki Enokida +13 more
TL;DR: In this article , the authors investigated the function of exosomal miR-1 and the possibility that the exosome constitutes a tumor maker in renal cell carcinoma (RCC) and established the method to collect exosomes from cell lysates and human serum by a spin column-based method.
18
Potential therapeutic target secretogranin II might cooperate with hypoxia-inducible factor 1α in sunitinib-resistant renal cell carcinoma.
W. Fukumoto,Hirofumi Yoshino,Shin-ichi Horike,Issei Kawakami,M. Tamai,Junya Arima,Ichiro Kawahara,Akihiko Mitsuke,Takashi Sakaguchi,Satoru Inoguchi,Makiko Meguro-Horike,Shuichi Tatarano,Hideki Enokida +12 more
TL;DR: SCG2 could be associated with sunitinib resistance through VEGF regulation in RCC cells through direct interaction between SCG2 and hypoxia‐inducible factor 1α (HIF1α) and coimmunoprecipitation assays revealed a direct interaction with HIF1 α.
5
Mp14-17 smarcd1 regulated by microrna-99a-5p contributes to gemcitabine resistance in bladder cancer via suppression of cellular senescence
Junya Arima,Hirofumi Yoshino,Ichiro Kawahara,W. Fukumoto,I. Kawakami,M. Tamai,Shuichi Tatarano,Hideki Enokida +7 more
TL;DR: Wang et al. as discussed by the authors found that miR-99a-5p overexpression or SMARCD1 down regulation induced cellular senescence with recovery of gemcitabine sensitivity.
Therapeutic strategies for MMAE-resistant bladder cancer through DPP4 inhibition.
Gang Li,Shuichi Tatarano,Hirofumi Yoshino,Saeki Saito,Mitsuhiko Tominaga,Junya Arima,Ikumi Fukuda,Takashi Sakaguchi,Ryosuke Matsushita,Yasutoshi Yamada,Hideki Enokida +10 more
TL;DR: This study explores MMAE-resistant bladder cancer through DPP4 inhibition, finding that DPP4 inhibitors, such as sitagliptin, can suppress cancer cell proliferation, induce apoptosis, and inhibit in vivo growth, providing a potential therapeutic strategy for MMAE-resistant bladder cancer.
Abstract 2442: Blood based novel mRNA genomic test, for screening, early detection, prognosis and monitoring of prostate cancer using a multi-center study
Yutaka Hashimoto,Shiv K. Verma,Guoren Deng,Dharam P. Chauhan,Sujit S. Nair,Dimple Chakravarty,Hirofumi Yoshino,Junya Arima,Shuichi Tatarano,Yutong Liu,Koji Hatano,Yogesh Shivakumar,Mithua Ghosh,Krishnappa Raghunath,Chitra Chandran,Narasimhan Ragavan,Hideki Enokida,Norio Nonomura,K.C. Balaji,Sudhir K Rawal,Ash Tewari,Rajvir Dahiya +21 more
TL;DR: A novel mRNA genomic test for screening, early detection, prognosis and monitoring of prostate cancer using blood samples has been developed and validated in a multi-center study. The test has high sensitivity and specificity and can stratify patients into distinct prognostic groups.