Junxi Wang

TL;DR: It is found that monocytes showed high transporter associated with antigen processing (TAP)-dependent peptide compartmentalization and that after antigen pulsing, they were not able to efficiently stimulate antigen-specific T lymphocytes, compatible with the model that during monocyte-to-DC differentiation, the subcellular relocation of TAP and the regulation of its activity assure spatiotemporal separation of local antigen uptake and processing by monocytes.

TL;DR: The results of this study suggest that in patients BT-061 would primarily induce CD4 down-modulation at inflammatory sites, implying that Fcγ receptor mediated cell-cell interactions played a role in this effect.

TL;DR: A method based on area under the ROC curve (AUC) values that indicates how much correlations of the biomarkers with the disease of interest exceed pure random effects is proposed.

TL;DR: This paper proposes a leaf ordering algorithm for the dendrogram that preserving the hierarchical clustering result tries to group instances from the same class together based on the concept of dynamic programming which can efficiently compute the optimal or nearly optimal order, consistent with the structure of the tree.