Junwang Gu
Nanchang University
9 Papers
Junwang Gu is an academic researcher from Nanchang University. The author has contributed to research in topics: Medicine & Ryanodine receptor. The author has an hindex of 5, co-authored 5 publications.
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Papers
The effect of lead exposure on expression of SIRT1 in the rat hippocampus
Chang Feng,Junwang Gu,Fankun Zhou,Jiaoyang Li,Gaochun Zhu,Linfu Guan,Haizhen Liu,Guihua Du,Jiangao Feng,Dong Liu,Shuyun Zhang,Guangqin Fan +11 more
TL;DR: Pb exposure decreased SIRT1 and CREB phosphorylation in a dose-dependent manner in the rat hippocampus at both PNW3 and 52, and resveratrol reversed those losses, indicating that Sirt1 might be a novel target to prevent Pb neurotoxicity.
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RyRs mediate lead-induced neurodegenerative disorders through calcium signaling pathways.
Fankun Zhou,Guihua Du,Jie Xie,Junwang Gu,Qiyue Jia,Ying Fan,Han Yu,Zhipeng Zha,Kai Wang,Lu Ouyang,Lijian Shao,Chang Feng,Guangqin Fan +12 more
TL;DR: It is determined that Pb-mediated upregulation of RyRs led to neurodegeneration via high levels of free calcium, depression of the calcium-dependent CaMKIIα/CREB mnemonic signaling pathway, and activation of the calcmodulin-dependent Erk/Bcl2 apoptotic signaling pathway.
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Relationship between body dissatisfaction, insufficient physical activity, and disordered eating behaviors among university students in southern China
TL;DR: Zhang et al. as discussed by the authors explored the relationship between body dissatisfaction, insufficient physical activity, and disordered eating behaviors among university students in southern China and found that university students with high body dissatisfaction had lower physical activity scores and higher restrained eating scores.
Lead exposure-induced cognitive impairment through RyR-modulating intracellular calcium signaling in aged rats.
Lu Ouyang,Wei Zhang,Guihua Du,Haizhen Liu,Jie Xie,Junwang Gu,Shuyun Zhang,Fankun Zhou,Lijian Shao,Chang Feng,Guangqin Fan +10 more
TL;DR: It is demonstrated that the lead concentration in peripheral blood and brain tissues in aged rats was significantly increased in a lead dose-dependent manner and indicated that early life lead exposure-induced cognition disorder was irreversible in aged Rats.
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Pb2+ modulates ryanodine receptors from the endoplasmic reticulum in rat brain.
Qiyue Jia,Guihua Du,Yu Li,Zhiping Wang,Jie Xie,Junwang Gu,Guangming Yin,Shuyun Zhang,Yanyan Gao,Fankun Zhou,Chang Feng,Guangqin Fan +11 more
TL;DR: This study indicates that RyRs are molecular targets of Pb2 +, and this interaction disturbs Ca2 + signals and leads to neurotoxicity.
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