Junran Sun
Shanghai Jiao Tong University
39 Papers
24 Citations
Junran Sun is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Medicine & Retinal pigment epithelium. The author has an hindex of 5, co-authored 13 publications.
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Papers
Choroidal pericytes promote subretinal fibrosis after experimental photocoagulation.
Xueting Luo,Shiqi Yang,Jian Liang,Yuanqi Zhai,Mengxi Shen,Junran Sun,Yiji Feng,Xinmin Lu,Hong Zhu,Fenghua Wang,Xiaodong Sun +10 more
TL;DR: It is demonstrated, by cell-lineage tracing, that pericytes associating with choroidal microvasculature are activated upon injury and infiltrate into the subretinal space as significant components of fibrotic lesions, and it is suggested that collagen 1-expressingpericytes are potential targets for therapeutic intervention to suppressSubretinal fibrosis and preserve vision.
TRIM31 inhibits NLRP3 inflammasome and pyroptosis of retinal pigment epithelial cells through ubiquitination of NLRP3
TL;DR: The results propose that TRIM31 could enhanceNLRP3 ubiquitination, therefore inhibiting NLRP3 inflammasome and pyroptosis in human RPE cells.
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Autophagy activated by SIRT6 regulates Aβ induced inflammatory response in RPEs.
Yiji Feng,Jian Liang,Yuanqi Zhai,Junran Sun,Jing Wang,Xiangjun She,Qing Gu,Yang Liu,Hong Zhu,Xueting Luo,Xiaodong Sun +10 more
TL;DR: It is found that expression of Sirtuin 6 (SIRT6) and autophagic markers are upregulated in RPEs of aged mice where subretinal deposition of amyloids-β is accumulated and in amyloid-β stimulated R PEs.
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Safety of Receiving Anti-Vascular Endothelial Growth Factor Intravitreal Injection in Office-Based vs Operating Room Settings: A Meta-analysis.
TL;DR: In this article, the authors evaluated the safety outcomes of IVI with anti-VEGF agents in the OR vs office-based setting, and the pooled rates of endophthalmitis (EO) and culture-positive EO were 0.03% and 0.02% (95% CI, 0.01-0.04, respectively).
METTL3-mediated m6A modification of HMGA2 mRNA promotes subretinal fibrosis and epithelial-mesenchymal transition.
Yuwei Wang,Yuhong Chen,Jian Liang,Mei Jiang,Ting Zhang,Xiaoling Wan,Jiahui Wu,Xiaomeng Li,Jieqiong Chen,Junran Sun,Yifan Hu,Peirong Huang,Jingyang Feng,Te Liu,Xiaodong Sun +14 more
TL;DR: Zhang et al. as mentioned in this paper found that during subretinal fibrosis in the mouse model of laser-induced choroidal neovascularization, METTL3 was upregulated in retinal pigment epithelial (RPE) cells.
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