Effect of hypoglycemic anti-deafness capsules in diabetic patients with deafness and toxicological assessment in rats.

Objective To study the efficacy and safety of the Jiang Tang Fang Long Jiao Nang (Hypoglycemic Anti-Deafness Capsule) in treating non-insulin dependent diabetes mellitus with hearing loss. Methods Two hundred ninety six patients with non-insulin dependent diabetes mellitus and hearing loss were randomly assigned to a treatment group(n=164, 208 ears) and a control group(n=132, 184 ears). Patients in the treatment group were treated with the Jiang Tang Fang Long Jiao Nang and supplement herbal preparations as indicated by traditional Chinese medicine dialectical assessment, while control patients received glibenclamide and conventional treatments for deafness. Hearing, fasting blood glucose(FBG), post-prandial blood glucose(PBG), 24 hour urine sugar, platelet function indices, blood superoxide dismutase(SOD) and lipid peroxides(LPO) levels, and symptom improvement were compared between the two groups. Results The rate of hearing improvement was 56.7% for the treatment group and 26.6% for the control. FBG, PBG and 24 hour urine sugar improved in both groups, but the last two were superior in the treatment group compared to the control. Symptoms improvement was also superior in the treatment group compared to the control. In patients receiving Jiang Tang Fang Long Jiao Nang treatment, platelet function indices, SOD and LPO were all improved, while only LOP improvement was noticed in control patients. No acute or long-term toxicity was demonstrated for the Jiang Tang Fang Long Jiao Nang in animal tests. The Jiang Tang Fang Long Jiao Nang lowered blood glucose and serum triglycerides in a rat model of alloxan-induced diabetes. Conclusion The Jiang Tang Fang Long Jiao Nang is effective in improving hearing and diabetic indices in diabetic patients with deafness, without significant side effects.

Jiang Tang Fang Long Jiao Nang in Treating Non-Insulin Dependent Diabetes Mellitus with Hearing Loss

Objective To study the influence in bone mineral density of diabetes with deafness in different syndrome types by Prescriptions of hypoglycemic preventing deafness. Methods We treated 42 patients (84 ears) of diabetes with deafness in different syndrome type by prescriptions of hypoglycemic prevent deafness. Then determinate bone gla protein (BGP), calcitonin (HCT), parathyroid hormone (PTH) and bone metabolic index of these patients before treatment and after treatment. We also maesured the bone mineral density of lumbar spine, femoral, arm, heel of these patient in treatment group. There were 40 normal people in control group. Results We compared the bone metabolism of patients with different syndromes in group treatment before the treatment with the normal people. Results show that BGP, HCT of patients with Yin scorching has no obvious statistical significance (P > 0.05). PTH of patients had gawped higher (P 0.05). Patient in qi and Yin deficiency, deficiency of Yin and Yang have obvious changes (P 0.05). Conclusion Prescriptions of hypoglycemic preventing deafness can improve the bone metabolism and bone mineral density of diabetes patients with deafness in different syndrome types. It can provide basis for diabetes-kidney-bone-ear integration hypothesis.

The Influence in Bone Mineral Density of Diabetes with Deafness in Different Syndrome Types by Prescriptions of Hypoglycemic Preventing Deafness

Objective to discuss the effect of the early intervention to the patients with hearing loss by the hypoglycemic anti-deaf party. Methods 44 (56 ears) patients with diabetes and deafness treat by the hypoglycemic anti-deaf party, control group of 40 healthy persons Refuses to accept any drug and observe the same number of days with the treatment group. All patients were given the control diet, diabetes knowledge, education, sports and other treatment. Measured the two groups fasting blood glucose (FBG), 2 h postprandial blood glucose (2 hPBG), glycosylated hemoglobin (HbAIc), FINS, insulin (2 hINS), TCM syndromes and compared the before and the after. Results After treatment, FBG, 2 hPBG HbAIc decreased significantly than before treatment (P 0.05). After treatment FINS, 2 hINS than before treatment decreased significantly (P 0.05) the two groups’ BMI before and after treatment had no statistically significant (P > 0.05) Before and after treatment syndromes treatment group than the control group. Conclusion Hypoglycemic anti-deaf glue combined to control diet, diabetes knowledge, education, sports, and other patients with hearing loss early treatment of diabetes was significantly lower FBG, 2 hPBG, HbAIc, improve insulin secretion, control diabetes and development.

A Studies of the Early Intervention to the Diabetic Patients with Hearing Loss by Hypoglycemic Anti-deaf Party

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The Influence in Bone Mineral Density of Diabetes with Deafness in Different Syndrome Types by Prescriptions of Hypoglycemic Preventing Deafness

A Studies of the Early Intervention to the Diabetic Patients with Hearing Loss by Hypoglycemic Anti-deaf Party