Junko Wakabayashi
Johns Hopkins University
11 Papers
30 Citations
Junko Wakabayashi is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Mitochondrion & DNAJA3. The author has an hindex of 11, co-authored 11 publications. Previous affiliations of Junko Wakabayashi include University of Tsukuba & Johns Hopkins University School of Medicine.
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Papers
Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation
Nobunao Wakabayashi,Ken Itoh,Junko Wakabayashi,Hozumi Motohashi,Shuhei Noda,Satoru Takahashi,Sumihisa Imakado,Tomoe Kotsuji,Fujio Otsuka,Dennis R. Roop,Takanori Harada,James Douglas Engel,Masayuki Yamamoto +12 more
TL;DR: These experiments show that Keap1 acts upstream of Nrf2 in the cellular response to oxidative and xenobiotic stress, and breeding to NRF2-deficient mice reversed the phenotypic Keap 1 deficiencies.
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The dynamin-related GTPase Drp1 is required for embryonic and brain development in mice
Junko Wakabayashi,Zhongyan Zhang,Nobunao Wakabayashi,Yasushi Tamura,Masahiro Fukaya,Thomas W. Kensler,Miho Iijima,Hiromi Sesaki +7 more
TL;DR: Brain-specific Drp1 knockout mice demonstrate thatDrp1-mediated organelle division is important for development, mitochondrial morphogenesis, and apoptosis.
Direct Membrane Association Drives Mitochondrial Fission by the Parkinson Disease-associated Protein α-Synuclein
Ken Nakamura,Venu M. Nemani,Farnaz Azarbal,Gaia Skibinski,Jon M. Levy,Kiyoshi Egami,Larissa A. Munishkina,Jue Zhang,Brooke M. Gardner,Junko Wakabayashi,Hiromi Sesaki,Yifan Cheng,Steven Finkbeiner,Robert L. Nussbaum,Eliezer Masliah,Robert H. Edwards +15 more
TL;DR: It is shown that the expression of α-synuclein in mammalian cells, including neurons in vitro and in vivo, causes the fragmentation of mitochondria.
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Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity.
Tae Yamamoto,Takafumi Suzuki,Akira Kobayashi,Junko Wakabayashi,Jon M. Maher,Hozumi Motohashi,Hozumi Motohashi,Masayuki Yamamoto,Masayuki Yamamoto +8 more
TL;DR: Critical roles of the cysteine residues in vivo in maintaining Keap1 function are demonstrated, such that Nrf2 is repressed under quiescent conditions and active in response to oxidants/electrophiles.
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Role of Nrf2 in prevention of high-fat diet-induced obesity by synthetic triterpenoid CDDO-imidazolide.
Soona Shin,Junko Wakabayashi,Melinda S. Yates,Nobunao Wakabayashi,Patrick M. Dolan,Susan Aja,Karen T. Liby,Michael B. Sporn,Masayuki Yamamoto,Thomas W. Kensler +9 more
TL;DR: It is indicated that CDDO-Im is an exceedingly potent agent for preventing obesity, and the Nrf2 pathway is identified as a novel target for management of obesogenesis.
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