Junjun Wu
Princeton University
15 Papers
305 Citations
Junjun Wu is an academic researcher from Princeton University. The author has contributed to research in topics: MAP kinase kinase kinase & Small molecule. The author has an hindex of 12, co-authored 15 publications.
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Papers
Identification of potent and selective MMP-13 inhibitors.
Junjun Wu,Thomas S. Rush,Rajeev Hotchandani,Xuemei Du,Mary Geck,Elisabeth Collins,Zhang-Bao Xu,J.S. Skotnicki,Jeremy I. Levin,Frank Lovering +9 more
TL;DR: IACS-4759 (compound 5), a sub-nanomolar inhibitor of MTH1 with excellent cell permeability and good metabolic stability in microsomes, proved to be an excellent tool for interrogation of the utility of M TH1 inhibition in the context of oncology.
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Acylguanidines as Small-Molecule β-Secretase Inhibitors
Derek Cecil Cole,E.S. Manas,Joseph Raymond Stock,Jeffrey Scott Condon,Lee D. Jennings,Ann Aulabaugh,Rajiv Chopra,Rebecca Cowling,John W. Ellingboe,Kristi Fan,Boyd L. Harrison,Yun Hu,Steve Jacobsen,Guixan Jin,Laura Lin,Frank E. Lovering,Michael S. Malamas,Mark L. Stahl,James Strand,Mohani N. Sukhdeo,Kristine Svenson,M. James Turner,Erik Wagner,Junjun Wu,and Ping Zhou,Jonathan A. Bard +25 more
TL;DR: In this article, small-molecule acylguanidine inhibitors of BACE1 were identified, which form unique hydrogen-bonding interactions with the catalytic site aspartic acids and stabilize the protein in a flap-open conformation.
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Inhibitors of Tumor Progression Loci-2 (Tpl2) Kinase and Tumor Necrosis Factor α (TNF-α) Production: Selectivity and in Vivo Antiinflammatory Activity of Novel 8-Substituted-4-anilino-6-aminoquinoline-3-carbonitriles
Neal Green,Yonghan Hu,Kristin Janz,Huan-Qiu Li,Neelu Kaila,Satenig Guler,Jennifer R. Thomason,Diane Joseph-McCarthy,Tam Steve Yik-Kai,Rajeev Hotchandani,Junjun Wu,Adrian Huang,Qin Wang,Louis Leung,Jefferey Pelker,Suzana Marusic,Sang Hsu,Jean-Baptiste Telliez,J. Perry Hall,John W. Cuozzo,Lih-Ling Lin +20 more
TL;DR: Modifications to the C-6 and C-8 positions led to the identification of compounds with increased inhibition of TNF-alpha release from LPS-stimulated rat and human blood, and these analogues were also highly selective for Tpl2 kinase over EGFR kinase.
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Selective inhibitors of tumor progression loci-2 (Tpl2) kinase with potent inhibition of TNF-alpha production in human whole blood.
Junjun Wu,Neal Jeffrey Green,Rajeev Hotchandani,Yonghan Hu,Jeffrey Scott Condon,Adrian Huang,Neelu Kaila,Huan-Qiu Li,Satenig Guler,Wei Li,Tam Steve Yik-Kai,Qin Wang,Jeffrey W. Pelker,Suzana Marusic,Sang Hsu,J. Perry Hall,Jean-Baptiste Telliez,Junqing Cui,Lih-Ling Lin +18 more
TL;DR: It is found that a cyclic amine group appended to the triazole ring could considerably enhance potency, aqueous solubility, and cell membrane permeability.
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Patent
3-Cyanoquinoline inhibitors of Tpl2 kinase and methods of making and using the same
Neal Jeffrey Green,Yonghan Hu,Neelu Kaila,Kristin Janz,Jennifer R. Thomason,Huan-Qiu Li,Rajeev Hotchandani,Junjun Wu,Ariamala Gopalsamy,Tam Steve Yik-Kai,Lih-Ling Lin,John W. Cuozzo,Satenig Guler,Adrian Huang,Jeffrey Scott Condon +14 more
- 12 May 2006
TL;DR: In this article, the authors provided compounds of formula (I): and pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, R7, R8, m and n are defined as described as described in this paper.
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