Junjun Chu
Sun Yat-sen University
12 Papers
Junjun Chu is an academic researcher from Sun Yat-sen University. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 7, co-authored 7 publications.
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Papers
Tamoxifen-resistant breast cancer cells are resistant to DNA-damaging chemotherapy because of upregulated BARD1 and BRCA1
Yinghua Zhu,Yujie Liu,Chao Zhang,Junjun Chu,Yanqing Wu,Yudong Li,Jieqiong Liu,Qian Li,Shunying Li,Qianfeng Shi,Liang Jin,Jianli Zhao,Dong Yin,Sol Efroni,Fengxi Su,Herui Yao,Erwei Song,Qiang Liu +17 more
TL;DR: It is reported that tamoxifen-resistant breast cancer cells express significantly more BARD1 and BRCA1, leading to resistance to DNA-damaging chemotherapy including cisplatin and adriamycin, but not to paclitaxel.
NBAT1 suppresses breast cancer metastasis by regulating DKK1 via PRC2.
Pengnan Hu,Junjun Chu,Yanqing Wu,Lijuan Sun,Xiao-Bin Lv,Yinghua Zhu,Jingjing Li,Qiannan Guo,Chang Gong,Bodu Liu,Shicheng Su +10 more
TL;DR: It is reported that NBAT1 is down-regulated in various types of cancer and is a potential breast cancer prognostic marker, as well as a potential therapeutic target to inhibit breast cancer metastasis.
E2F7 overexpression leads to tamoxifen resistance in breast cancer cells by competing with E2F1 at miR-15a/16 promoter.
Junjun Chu,Yinghua Zhu,Yujie Liu,Lijuan Sun,Xiao-Bin Lv,Yanqin Wu,Pengnan Hu,Fengxi Su,Chang Gong,Erwei Song,Bodu Liu,Qiang Liu +11 more
TL;DR: The results suggest that overexpression of E2F7 represses miR-15a/16 and then increases Cyclin E1 and Bcl-2 that result in tamoxifen resistance.
73
The Role of APAL/ST8SIA6-AS1 lncRNA in PLK1 Activation and Mitotic Catastrophe of Tumor Cells
Man-Li Luo,Jingjing Li,Liping Shen,Junjun Chu,Qiannan Guo,Guorun Liang,Wei Wu,Jianing Chen,Rufu Chen,Erwei Song +9 more
TL;DR: Overexpressing APAL accelerates cancer cell cycle progression, promotes proliferation and inhibits chemotherapy-induced apoptosis, and Mechanism studies show that APAL links upPLK1 and Aurora A to enhance Aurora A-mediated PLK1 phosphorylation.
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Mitochondrial fission determines cisplatin sensitivity in tongue squamous cell carcinoma through the BRCA1–miR-593-5p–MFF axis
Song Fan,Bodu Liu,Lijuan Sun,Xiao-Bin Lv,Zhaoyu Lin,Weixiong Chen,Wei-liang Chen,Qiong-lan Tang,You-yuan Wang,Yu-xiong Su,Shaowen Jin,Da-ming Zhang,Jianglong Zhong,Yilin Li,Bin Wen,Zhang Zhang,Pu Yang,Bin Zhou,Qixiang Liang,Xing Yu,Yinghua Zhu,Pengnan Hu,Junjun Chu,Wei Huang,Yu-Huan Feng,Hongzhuang Peng,Qihong Huang,Erwei Song,Jinsong Li +28 more
TL;DR: It is shown that MFF mediated mitochondrial fission and apoptosis in tongue squamous cell carcinoma (TSCC) cells after cisplatin treatment and that miR-593-5p was downregulated in this process, revealing a model for mitochondrial fissions regulation at the transcriptional and post-transcriptional levels.