7 Papers
8 Citations
Junjie Gu is an academic researcher from Peking Union Medical College Hospital. The author has contributed to research in topics: Cancer & Survivin. The author has an hindex of 2, co-authored 7 publications.
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Papers
The role of PKM2 nuclear translocation in the constant activation of the NF-κB signaling pathway in cancer-associated fibroblasts.
Junjie Gu,Xuechun Li,Lin Zhao,Ying Yang,Chunling Xue,Yang Gao,Jing Li,Qin Han,Zhao Sun,Chunmei Bai,Robert Chunhua Zhao,Robert Chunhua Zhao +11 more
TL;DR: It is proved that P300 inhibitors can inhibit tumor proliferation in an AGS subcutaneous xenograft tumor model and provide a new therapeutic target for CAF normalization or deactivation strategies.
Cancer-Associated Fibroblasts Promote the Upregulation of PD-L1 Expression Through Akt Phosphorylation in Colorectal Cancer
Yang Gao,Zhao Sun,Junjie Gu,Zhe Li,Xiuxiu Xu,Chunling Xue,Xuechun Li,Lin Zhao,Jianfeng Zhou,Chunmei Bai,Qin Han,Robert Chunhua Zhao,Robert Chunhua Zhao +12 more
TL;DR: In this article, the authors found that CAFs upregulated PD-L1 expression in colorectal cancer cells through AKT phosphorylation, thereby reducing the killing of CRC cells by peripheral blood mononuclear cells.
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Immunohistochemical detection of cancer-associated fibroblasts in gastrointestinal cancer as a potential prognostic biomarker of survival: meta-analysis
TL;DR: A meta-analysis of clinical trials published in the literature indicates that high proportion of CAFs is a valuable predictor of the prognosis in gastrointestinal cancer patients, and it may provide new ideas for targeted therapy inintestinal cancer patients.
The expression of versican and its role in pancreatic neuroendocrine tumors.
TL;DR: A previous study found VCAN had a tumor-specific expression in pNET tissues and found the relationship between VCAN expression and disease-free survival (DFS) of patients was unclear.
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The expression of pAKT/survivin and their role in colorectal cancer.
TL;DR: This data indicates that soluble factors released by carcinoma-associated fibroblasts can induce the translocation of AKT, Survivin, P38 to the nucleus of tumor cells, which might be the mechanism of microenvironment-mediated drug resistance to nonspecific conventional chemotherapeutic agents, such as platinum compounds or 5-FU.
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