Junjiang Sun
University of North Carolina at Chapel Hill
36 Papers
68 Citations
Junjiang Sun is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Factor IX & Hemarthrosis. The author has an hindex of 14, co-authored 31 publications. Previous affiliations of Junjiang Sun include East China University of Science and Technology.
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Papers
Optimization of Self-complementary AAV Vectors for Liver-directed Expression Results in Sustained Correction of Hemophilia B at Low Vector Dose
Zhijian Wu,Junjiang Sun,Tai-Ping Zhang,Chaoying Yin,Fang Yin,Terry Van Dyke,Richard Jude Samulski,Paul E. Monahan +7 more
TL;DR: The ability of low dose scAAV-FIX vectors to achieve near-physiological expression may circumvent inflammatory responses in the liver, and underscore the need for rigorous analysis and optimization of vector genome cassettes.
184
Double-stranded RNA innate immune response activation from long-term adeno-associated virus vector transduction
Wenwei Shao,Lauriel F. Earley,Zheng Chai,Xiaojing Chen,Junjiang Sun,Ting He,Meng Deng,Matthew L. Hirsch,Jenny P.-Y. Ting,R. Jude Samulski,Chengwen Li +10 more
TL;DR: Mechanistic analysis demonstrated that the double-stranded RNA (dsRNA) sensor MDA5 was necessary for innate immune response activation and that transient knockdown of Mda5, or MAVS, decreased IFN-β expression while increasing transgene production in AAV-transduced cells.
NIM811 Prevents Mitochondrial Dysfunction, Attenuates Liver Injury and Stimulates Liver Regeneration after Massive Hepatectomy
Hasibur Rehman,Junjiang Sun,Yanjun Shi,Venkat K. Ramshesh,Qinglong Liu,Robert T. Currin,John J. Lemasters,Zhi Zhong +7 more
TL;DR: NIM811 minimized liver injury and improved liver regeneration after MHX, at least in part, by preventing MPT onset and subsequent compromised energy supply and proapoptotic cytochrome c release.
Direct interaction of human serum proteins with AAV virions to enhance AAV transduction: immediate impact on clinical applications
M Wang,Junjiang Sun,A Crosby,Kenton T. Woodard,Matthew L. Hirsch,Richard Jude Samulski,Chengwen Li +6 more
TL;DR: In conclusion, incubation of HSA with AAV vectors supports a universal augmentation of AAV transduction and, more importantly, this approach can be immediately transitioned to the clinic for the treatment of hemophilia and other diseases.
44
Joint bleeding in factor VIII deficient mice causes an acute loss of trabecular bone and calcification of joint soft tissues which is prevented with aggressive factor replacement
Anthony G. Lau,Junjiang Sun,William B. Hannah,Eric W. Livingston,Dominique Heymann,Ted A. Bateman,Paul E. Monahan +6 more
TL;DR: Knee joint haemorrhage resulted in acute changes in adjacent bone including loss of bone density and mineralization of joint soft tissues including the tendons, ligaments, menisci and cartilage, which prevented bone and soft tissue degeneration.