Junichi Kuroyanagi
Daiichi Sankyo
18 Papers
95 Citations
Junichi Kuroyanagi is an academic researcher from Daiichi Sankyo. The author has contributed to research in topics: Benzoxazole & Prodrug. The author has an hindex of 7, co-authored 18 publications.
Chat about Author
Papers
1,3-Benzoxazole-4-carbonitrile as a novel antifungal scaffold of β-1,6-glucan synthesis inhibitors.
Junichi Kuroyanagi,Kazuo Kanai,Yuuichi Sugimoto,Takao Horiuchi,Issei Achiwa,Hiroshi Takeshita,Katsuhiro Kawakami +6 more
TL;DR: 1,3-Benzoxazole-4-carbonitrile 6 showed potent activity against Candida species compared to 5-desmethyl compound 4 and triazolopyridine 2 and was efficiently prepared from versatile intermediate 24.
42
Novel antifungal agents: Triazolopyridines as inhibitors of β-1,6-glucan synthesis
Junichi Kuroyanagi,Kazuo Kanai,Yuuichi Sugimoto,Tetsunori Fujisawa,Chikanori Morita,Takashi Suzuki,Katsuhiro Kawakami,Makoto Takemura +7 more
TL;DR: Among those scaffolds, triazolopyridine was found to be the specific inhibitor of the synthesis of beta-1,6-glucan, an essential component of the fungal cell wall, and to show potent antifungal activities against several Candida species.
35
Design, synthesis, and biological evaluations of novel 7-[7-amino-7-methyl-5-azaspiro[2.4]heptan-5-yl]-8-methoxyquinolines with potent antibacterial activity against respiratory pathogens.
Takashi Odagiri,Hiroaki Inagaki,Yuichi Sugimoto,Masatoshi Nagamochi,Rie Miyauchi,Junichi Kuroyanagi,Takahiro Kitamura,Satoshi Komoriya,Hisashi Takahashi +8 more
TL;DR: Compound 2a showed excellent in vivo activity against the experimental murine pneumonia model due to multidrug resistant Streptococcus pneumoniae (MDRSP) and favorable profiles in preliminary toxicological and nonclinical pharmacokinetic studies.
35
Discovery of novel pyridazine derivatives as glucose transporter type 4 (GLUT4) translocation activators.
Takashi Tsuji,Mitsuhiro Yamaguchi,Junichi Kuroyanagi,Shinji Furuzono,Masahiro Konishi,Koji Terayama,Jun Tanaka,Motoko Saito,Yoshiyuki Kobayashi +8 more
TL;DR: Promising compound 26b showed a significant blood glucose lowering effect in the severe diabetic mice model (10-week aged db/db mice) after oral dosing even at 10 mg/kg, implying that the pyridazine derivatives have potential to become novel therapeutic agents for diabetes mellitus.
23
Structure-activity relationships of 1,3-benzoxazole-4-carbonitriles as novel antifungal agents with potent in vivo efficacy.
Junichi Kuroyanagi,Kazuo Kanai,Takao Horiuchi,Hiroshi Takeshita,Shozo Kobayashi,Issei Achiwa,Kumi Yoshida,Koichi Nakamura,Katsuhiro Kawakami +8 more
TL;DR: A series of 1,3-benzoxazole-4-carbonitriles was synthesized and evaluated for its antifungal activity, solubility, and metabolic stability and compound 16b showed potent in vivo efficacy against mice Candida infection models and good bioavailability in rats.
20