Junichi Azuma
Hyogo University of Health Sciences
8 Papers
13 Citations
Junichi Azuma is an academic researcher from Hyogo University of Health Sciences. The author has contributed to research in topics: Taurine & Unfolded protein response. The author has an hindex of 6, co-authored 8 publications. Previous affiliations of Junichi Azuma include Hyogo University.
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Papers
Tissue depletion of taurine accelerates skeletal muscle senescence and leads to early death in mice.
Takashi Ito,Natsumi Yoshikawa,Takaaki Inui,Natsuko Miyazaki,Stephen W. Schaffer,Junichi Azuma +5 more
TL;DR: The data reveal that tissue taurine depletion affects longevity and cellular senescence; an effect possibly linked to a disturbance in protein folding.
Tissue taurine depletion alters metabolic response to exercise and reduces running capacity in mice.
TL;DR: A crucial role of taurine in regulating energy metabolism in skeletal muscle of exercising TauTKO mice is suggested, changes that contribute to impaired exercise endurance.
Role of protein phosphorylation in excitation-contraction coupling in taurine deficient hearts
TL;DR: The observation that taurine deficient hearts develop systolic and diastolic defects related to reduced SR Ca(2+) ATPase activity is supported, a change mediated in part by reduced phospholamban phosphorylation.
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Does taurine prolong lifespan by improving heart function
Stephen W. Schaffer,K. C. Ramila,Chian Ju Jong,Aza Shetewy,Kayoko Shimada,Takashi Ito,Junichi Azuma,Eugene A. Cioffi +7 more
TL;DR: One of the major mechanisms underlying the development of the cardiomyopathy is impaired sarcoplasmic reticular Ca2+ handling, which arises from a series of steps that include elevated protein phosphatase 1 activity, diminished Ca2-calmodulin-dependent protein kinase II (CaMKII) activity, reduced levels of phosphorylated phospholamban and finally impaired SR Ca2 + ATPase activity.
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The quest for an animal model of diabetic nephropathy and the role of taurine deficiency.
Xiaobin Han,Xiaobin Han,Takashi Ito,Junichi Azuma,Stephen W. Schaffer,Russell W. Chesney,Russell W. Chesney +6 more
TL;DR: Evidence is provided that alteration of the TauT gene has a substantial effect on the susceptibility to diabetic kidney disease development in a TauT −/− mouse model of diabetes, which closely replicates the pathological features of diabetic nephropathy in human diabetic patients and, thus, can serve as a model for therapeutic strategies.
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