Jun Yu

TL;DR: These studies unambiguously characterize 3 distinct models of the natural course of pneumococcal infection, which provides a framework for detailed molecular modeling ofneumococcal virulence determinants at specific stages of disease.

TL;DR: The existing foreign-body and deep-wound mouse models of staphylococcal infection are adapted to allow real-time monitoring of the bacterial colonization of catheters or tissues and enables kinetic measurements of bacterial growth and clearance in each infected animal.

TL;DR: A catheter-based biofilm infection model with mice that easily allows spatial information to be monitored sequentially throughout the entire disease process, including ascending UTI, treatment efficacy, and relapse, all without exogenous sampling, which is not possible with conventional methods.

TL;DR: Noninvasive real-time in vivo bioluminescent imaging was used to assess the spread of Streptococcus pneumoniae throughout the spinal cord and brain during the acute stages of bacterial meningitis, providing temporal, sequential, and spatial distribution of bacteria within the brain and spinal cord throughout the entire disease process.