Jun Yokota
National Cancer Research Institute
5 Papers
29 Citations
Jun Yokota is an academic researcher from National Cancer Research Institute. The author has contributed to research in topics: Gene & DDB1. The author has an hindex of 5, co-authored 5 publications.
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Papers
Genetic polymorphisms and alternative splicing of the hOGG1 gene, that is involved in the repair of 8-hydroxyguanine in damaged DNA
Takashi Kohno,Kazuya Shinmura,Kazuya Shinmura,Masahiko Tosaka,Masachika Tani,Su-Ryang Kim,Haruhiko Sugimura,Takehiko Nohmi,Hiroshi Kasai,Jun Yokota +9 more
TL;DR: The results suggest that the oh8Gua levels are maintained at a steady level, even though multiple hOGG1 proteins are produced due to genetic polymorphisms, mutations and alternative splicing of the hOGg1 gene.
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Cloning of a human homolog of the yeast OGG1 gene that is involved in the repair of oxidative DNA damage
Kiyomitsu Arai,Kiyomitsu Arai,Kazuhiro Morishita,Kazuya Shinmura,Takashi Kohno,Su-Ryang Kim,Takehiko Nohmi,Masafumi Taniwaki,Susumu Ohwada,Jun Yokota +9 more
TL;DR: The results strongly suggest that the gene isolated here is a human counterpart of the yeast OGGI gene and is involved in the repair of oxidative DNA damage in human cells.
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8-hydroxyguanine (7,8-dihydro-8-oxoguanine) DNA glycosylase and AP lyase activities of hOGG1 protein and their substrate specificity
TL;DR: The results indicate that the dominant function of hOGG1 protein is a oh8Gua glycosylase reaction by specifically recognizing oh8 Gua and pyrimidine opposite the oh8gua and delta-elimination reaction in the same manner as yOGG 1 protein.
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Genomic structure and chromosomal localization of the mouse Ogg1 gene that is involved in the repair of 8-hydroxyguanine in DNA damage.
Masachika Tani,Kazuya Shinmura,Takashi Kohno,Toshihiko Shiroishi,Shigeharu Wakana,Su-Ryang Kim,Takehiko Nohmi,Hiroshi Kasai,Seiichi Takenoshita,Yukio Nagamachi,Jun Yokota +10 more
TL;DR: This study isolated a mouse homolog (Ogg1) of the OGG1 gene, characterized oh8Gua-specific DNA glycosylase/AP lyase activities of its product, and determined chromosomal localization and exon-intron organization of this gene.
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Presence of human cellular protein(s) that specifically binds and cleaves 8-hydroxyguanine containing DNA
Makoto Nagashima,Makoto Nagashima,Atsushi Sasaki,Kazuhiro Morishita,Seiichi Takenoshita,Yukio Nagamachi,Hiroshi Kasai,Jun Yokota +7 more
TL;DR: Results indicate the presence of a protein(s) that is involved in a DNA repair pathway for the correction of the oh8Gua residue in human cells.
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