Jun Yan
Paris Diderot University
9 Papers
11 Citations
Jun Yan is an academic researcher from Paris Diderot University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 3, co-authored 4 publications. Previous affiliations of Jun Yan include Sorbonne.
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Papers
Integrative genomics of microglia implicates DLG4 (PSD95) in the white matter development of preterm infants.
Michelle L. Krishnan,Juliette Van Steenwinckel,Anne-Laure Schang,Jun Yan,Johanna Arnadottir,Tifenn Le Charpentier,Zsolt Csaba,Pascal Dournaud,Sara Cipriani,Constance Auvynet,Luigi Titomanlio,Julien Pansiot,Gareth Ball,James P. Boardman,Andrew Walley,Alka Saxena,Ghazala Mirza,Ghazala Mirza,Bobbi Fleiss,Bobbi Fleiss,A. David Edwards,Enrico Petretto,Pierre Gressens,Pierre Gressens +23 more
TL;DR: It is found that microglial expression of DLG4 plays a role in brain development and impacts inter-individual susceptibility to injury after preterm birth, as well as being associated with structural differences in the preterm infant brain.
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Oligodendrocyte precursor survival and differentiation requires chromatin remodeling by Chd7 and Chd8.
Corentine Marie,Adrien Clavairoly,Magali Frah,Hatem Hmidan,Jun Yan,Chuntao Zhao,Juliette Van Steenwinckel,Romain Daveau,Bernard Zalc,Bassem A. Hassan,Jean-Leon Thomas,Jean-Leon Thomas,Pierre Gressens,Philippe Ravassard,Ivan Moszer,Donna M. Martin,Q. Richard Lu,Carlos Parras +17 more
TL;DR: It is shown that Chd 7 protects OPCs from apoptosis by chromatin closing and gene repression of p53, while Chd7 induces chromatin opening and gene activation of OPC-differentiation regulators, which offer new avenues to understand and modulate the CHD7 and CHD8 functions in normal development and disease.
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Met-RANTES preserves the blood–brain barrier through inhibiting CCR1/SRC/Rac1 pathway after intracerebral hemorrhage in mice
Jun Yan,Weilin Xu,Cameron Lenahan,Lei Huang,Umut Ocak,Jing Wen,Gaigai Li,Weiman He,Chen-Sheng Le,John H. Zhang,Ligen Mo,Jiping Tang +11 more
TL;DR: The authors showed that CCR5 inhibition by Met-R improves neurological deficits after ICH by preserving BBB integrity through inhibiting CCR1/SRC/Rac1 signaling pathway in mice.
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Autophagy regulates inflammation in intracerebral hemorrhage: Enemy or friend?
Kai-Yuan Fu,Weilin Xu,Cameron Lenahan,Yong Mo,Jing Wen,Teng Deng,Qianrong Huang,Fang-Zhou Guo,Ligen Mo,Jun Yan +9 more
TL;DR: In this article , the authors explored the mutual regulation of autophagy and inflammation in intra-brachial hemorrhage (ICH) and found that autophagia plays a critical role in the pathology of ICH, and its function remains controversial.
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Met-RANTES preserves the blood–brain barrier through inhibiting CCR1/SRC/Rac1 pathway after intracerebral hemorrhage in mice
Jun Yan,Weilin Xu,Cameron Lenahan,Lei Huang,Umut Ocak,Jing Wen,Gaigai Li,W. He,Chen-Sheng Le,John H. Zhang,Ligen Mo,Jiping Tang +11 more
TL;DR: The authors showed that CCR5 inhibition by Met-R improves neurological deficits after ICH by preserving BBB integrity through inhibiting CCR1/SRC/Rac1 signaling pathway in mice.