Jun Xiao
Chinese Academy of Sciences
28 Papers
63 Citations
Jun Xiao is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Inflammation & Biology. The author has an hindex of 14, co-authored 24 publications.
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Papers
YAP Aggravates Inflammatory Bowel Disease by Regulating M1/M2 Macrophage Polarization and Gut Microbial Homeostasis.
Xin Zhou,Weiyun Li,Shuang Wang,Panli Zhang,Qiong Wang,Jun Xiao,Chi Zhang,Xin Zheng,Xiaoyan Xu,Shengjie Xue,Lijian Hui,Hongbin Ji,Bin Wei,Bin Wei,Hongyan Wang +14 more
TL;DR: YAP in macrophages aggravates IBD, accompanied by the production of antimicrobial peptides and changes in gut microbiota, and this study suggests that fully understanding the multiple functions of YAP in different cell types is crucial for IBD therapy.
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Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection.
Jun Xiao,Weiyun Li,Xin Zheng,Linlin Qi,Hui Wang,Chi Zhang,Xiaopeng Wan,Yuxiao Zheng,Ruiyue Zhong,Xin Zhou,Yao Lu,Zhiqi Li,Ying Qiu,Chang Liu,Fang Zhang,Yanbo Zhang,Yanbo Zhang,Xiaoyan Xu,Xiaoyan Xu,Zhongzhou Yang,Hualan Chen,Qiwei Zhai,Bin Wei,Bin Wei,Hongyan Wang,Hongyan Wang +25 more
TL;DR: This work has shown that upon DNA and RNA viral infection, macrophages reduced 7-dehydrocholesterol reductase (DHCR7) expression and it was elucidated that viral infection or 7-DHC treatment enhanced AKT3 expression and activation.
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STK4 regulates TLR pathways and protects against chronic inflammation–related hepatocellular carcinoma
Weiyun Li,Jun Xiao,Xin Zhou,Ming Xu,Chaobo Hu,Xiaoyan Xu,Yao Lu,Chang Liu,Shengjie Xue,Lei Nie,Haibin Zhang,Zhiqi Li,Yanbo Zhang,Fu Ji,Lijian Hui,Wufan Tao,Bin Wei,Hongyan Wang +17 more
TL;DR: It is demonstrated that the tumor suppressor serine/threonine-protein kinase 4 (STK4) differentially regulates TLR3/4/9-mediated inflammatory responses in macrophages and thereby is protective against chronic inflammation-associated HCC.
Polyphyllin I Ameliorates Collagen-Induced Arthritis by Suppressing the Inflammation Response in Macrophages Through the NF-κB Pathway
Qiong Wang,Xin Zhou,Yongjian Zhao,Jun Xiao,Yao Lu,Qi Shi,Yongjun Wang,Hongyan Wang,Qianqian Liang +8 more
TL;DR: PI demonstrated effective amelioration of synovial inflammation in the ankle joint of CIA mice while suppressing NF-κB-mediated production of pro-inflammatory effectors in activated macrophages.
M-CSF, IL-6, and TGF-β promote generation of a new subset of tissue repair macrophage for traumatic brain injury recovery
Zhiqi Li,Jun Xiao,Xiaoyan Xu,Xiaoyan Xu,Weiyun Li,Weiyun Li,Ruiyue Zhong,Linlin Qi,Linlin Qi,Jiehui Chen,Guizhong Cui,Shuang Wang,Yuxiao Zheng,Ying Qiu,Sheng Li,Xin Zhou,Xin Zhou,Yao Lu,Jiaying Lyu,Bin Zhou,Jiawei Zhou,Naihe Jing,Bin Wei,Bin Wei,Bin Wei,Jin Hu,Hongyan Wang,Hongyan Wang +27 more
TL;DR: In this paper, the key cytokines favoring TBI repair were identified and found that patients with TBI with a better outcome robustly increased concentrations of macrophage colony-stimulating factor, interleukin-6, and transforming growth factor β (termed M6T) in cerebrospinal fluid or plasma.
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