The yellow pigment curcumin, extracted from turmeric, is a renowned polyphenol with a broad spectrum of health properties such as antioxidant, anti-inflammatory, anti-cancer, antidiabetic, hepatoprotective, anti-allergic, anti-dermatophyte, and neuroprotective. However, these properties are followed by a poor pharmacokinetic profile which compromises its therapeutic potential. The association of low absorption by the small intestine and the extensive reductive and conjugative metabolism in the liver dramatically weakens the oral bioavailability. Several strategies such as inhibition of curcumin metabolism with adjuvants as well as novel solid and liquid oral delivery systems have been tried to counteract curcumin poor absorption and rapid elimination from the body. Some of these drug deliveries can successfully enhance the solubility, extending the residence in plasma, improving the pharmacokinetic profile and the cellular uptake.

Dietary Curcumin: Correlation between Bioavailability and Health Potential.

Fabrication and characterization of microcapsule encapsulating EOR surfactants by microfluidic technique

ZSM-5 (Seolite Sconoy Mobil) aluminosilicate zeolites synthesized by the hydrothermal method were incorporated into the hydrophobic ethyl cellulose (EC) nanofibrous membrane. The performance of synthesized nanofibers was investigated for a gravity driven oil–water separation. The synthesized ZSM-5 nanozeolites and EC/ZSM-5 composite nanofibers were characterized using XRD, FESEM, XPS, FTIR and AFM analysis. The permeability of EC/ZSM-5 5 wt% for oil in water mixture was in order of n-hexane (5170 ± 60 L/m2 h) > n-heptane (4600 ± 50 L/m2 h) > cyclohexane (4350 ± 35 L/m2 h) > pump oil (3780 ± 28 L/m2 h) > lubricating oil (3200 ± 25 L/m2 h) > motor oil (2980 ± 20 L/m2 h) with a separation efficiency higher than 99.90% for the studied oil/water mixtures separation. The potential of nanofibers toward oil absorption from oil/water mixtures was also investigated for 7 cycles of absorption process. The absorption capacity was found to be 525.6, 423.4 and 198.3 g/g for motor oil, cyclohexane and n-heptane using EC/ZSM-5 nanofibers. The obtained results revealed that ZSM-5 loaded-EC nanofibrous membranes can be used as efficient membranes for oil/water separation.

Synthesis of ethyl cellulose/aluminosilicate zeolite nanofibrous membranes for oil–water separation and oil absorption

One-step emulsification for controllable preparation of ethyl cellulose microcapsules and their sustained release performance.

In this study, a high-voltage electrostatic technique is introduced to prepare polycarbonate (PC) microspheres in order to design an expansion strategy for the bone marrow mesenchymal stem cells (BMMSCs). The effects of the solution concentration, temperature, nozzle specification and voltage on the sphericity, homogeneity, diameter and sedimentation velocities of the microspheres are investigated. By optimising the preparation parameters, PC microspheres with a diameter of 316.39 μm ± 14.75 μm and porous surface were prepared. The gelatine-modified PC (GEL-PC) microspheres exhibited better hydrophilicity and protein adsorption ability than PC microspheres. Enhancement of the adhesion and proliferation of the BMMSCs can be observed on GEL-PC microspheres after 7 days. Therefore, this study demonstrates that employing a dynamic culture using GEL-PC microspheres is a promising method for deriving BMMSCs.

Preparation of polycarbonate/gelatine microspheres using a high-voltage electrostatic technique for enhancing the adhesion and proliferation of mesenchymal stem cells

In vitro and in vivo evaluation of curcumin loaded hollow microspheres prepared with ethyl cellulose and citric acid.

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In vitro and in vivo evaluation of curcumin loaded hollow microspheres prepared with ethyl cellulose and citric acid.