12 Papers
2 Citations
Jun Tu is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: SUMO protein & Biology. The author has an hindex of 3, co-authored 9 publications.
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Papers
SENP1-Sirt3 Signaling Controls Mitochondrial Protein Acetylation and Metabolism.
Tianshi Wang,Ying Cao,Quan Zheng,Jun Tu,Wei Zhou,Jianli He,Jie Zhong,Yalan Chen,Jiqiu Wang,Rong Cai,Yong Zuo,Bo Wei,Qiuju Fan,Jie Yang,Yicheng Wu,Jing Yi,Dali Li,Mingyao Liu,Chuangui Wang,Aiwu Zhou,Aiwu Zhou,Yu Li,Xuefeng Wu,Wen Yang,Y. Eugene Chin,Guo-Qiang Chen,Jinke Cheng +26 more
TL;DR: Sirt3 SUMOylation mutation reduces fat mass and antagonizes high-fat diet (HFD)-induced obesity via increasing oxidative phosphorylation and energy expenditure and the results reveal that SENP1-Sirt 3 signaling modulates Sirt3 activation and mitochondrial metabolism during metabolic stress.
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Glucose limitation activates AMPK coupled SENP1-Sirt3 signalling in mitochondria for T cell memory development.
Jianli He,Xun Shangguan,Wei Zhou,Ying Cao,Quan Zheng,Jun Tu,Gaolei Hu,Zi Liang,Cen Jiang,Liufu Deng,Shengdian Wang,Wen Yang,Yong Zuo,Jiao Ma,Rong Cai,Yalan Chen,Qiuju Fan,Baijun Dong,Wei Xue,Hongsheng Tan,Yitao Qi,Jianmin Gu,Bing Su,Y. Eugene Chin,Guo-Qiang Chen,Qi Wang,Tianshi Wang,Jinke Cheng +27 more
TL;DR: In this article, the SUMO protease SENP1-Sirt3 signalling augments the deacetylase activity of Sirt3, promoting both OXPHOS and mitochondrial fusion.
DUSP6 SUMOylation protects cells from oxidative damage via direct regulation of Drp1 dephosphorylation.
Ruining Ma,Lina Ma,Weiji Weng,Yingping Wang,Huiqing Liu,Rongjun Guo,Yingwei Gao,Jun Tu,Tian-Le Xu,Jinke Cheng,Michael X. Zhu,Aiwu Zhou,Yong Li +12 more
TL;DR: DUSP6 exerts a cytoprotective role by directly dephosphorylating Drp1-S616, which is disrupted by deSUMOylation under oxidation.
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SENP1-Sirt3 signaling promotes α-ketoglutarate production during M2 macrophage polarization.
Wei Zhou,Gaolei Hu,Jianli He,Tianshi Wang,Yong Zuo,Ying Cao,Quan Zheng,Jun Tu,Jiao Ma,Rong Cai,Yalan Chen,Qiuju Fan,Baijun Dong,Hongsheng Tan,Qi Wang,W. Xu,Jinke Cheng +16 more
TL;DR: In this article , the SENP1-Sirt3 axis was shown to play a critical role in α-ketoglutarate (αKG) accumulation via glutaminolysis to promote M2 polarization.
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SIRT3-mediated deacetylation of NLRC4 promotes inflammasome activation
Chenyang Guan,Xian Huang,Jinnan Yue,Hongrui Xiang,Samina Shaheen,Zhenyan Jiang,Yuexiao Tao,Jun Tu,Zhenshan Liu,Yufeng Yao,Wen Yang,Zhaoyuan Hou,Junling Liu,Xiao Dong Yang,Qiang Zou,Bing Su,Zhiduo Liu,Jun Ni,Jinke Cheng,Xuefeng Wu +19 more
TL;DR: It is proved that deacetylation of NLRC4 at Lys71 or Lys272 could promote its activation and the acetylation switch ofNLRC4 may aid the clearance of S. typhimurium infection.
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