22 Papers
144 Citations
Jun Sun is an academic researcher from University of Illinois at Urbana–Champaign. The author has contributed to research in topics: Estrogen receptor & Estrogen receptor alpha. The author has an hindex of 17, co-authored 19 publications. Previous affiliations of Jun Sun include Urbana University & University of Illinois at Chicago.
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Papers
Pyrazole Ligands: Structure−Affinity/Activity Relationships and Estrogen Receptor-α-Selective Agonists
Shaun R. Stauffer,Christopher J Coletta,Rosanna Tedesco,Gisele Nishiguchi,Kathryn E. Carlson,Jun Sun,Benita S. Katzenellenbogen,John A. Katzenellenbogen +7 more
TL;DR: Investigations suggest that the pyrazole triols prefer to bind to ERalpha with their C(3)-phenol in the estradiol A-ring binding pocket and that binding selectivity results from differences in the interaction of thePyrazole core and C(4)-propyl group with portions of the receptor where ERalpha has a smaller residue than ERbeta.
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Estrogen receptor-beta potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues.
Marvin J. Meyers,Jun Sun,Kathryn E. Carlson,Gwendolyn A. Marriner,Benita S. Katzenellenbogen,John A. Katzenellenbogen +5 more
TL;DR: This study suggests that, in this series of ligands, the nitrile functionality is critical to ERbeta selectivity because it provides the optimal combination of linear geometry and polarity.
724
Novel ligands that function as selective estrogens or antiestrogens for estrogen receptor-alpha or estrogen receptor-beta.
Jun Sun,Marvin J. Meyers,Brian E. Fink,Ramji R. Rajendran,John A. Katzenellenbogen,Benita S. Katzenellenbogen +5 more
TL;DR: These compounds should be useful in probing the conformational changes in these two ERs that are evoked by agonists and antagonists, and in evaluating the distinct roles that ER beta and ER alpha may play in the diverse target tissues in which estrogens act.
Molecular mechanisms of estrogen action: selective ligands and receptor pharmacology.
Benita S. Katzenellenbogen,Inho Choi,Régis Delage-Mourroux,Tracy R. Ediger,Paolo G. V. Martini,Monica M. Montano,Jun Sun,Karen E. Weis,John A. Katzenellenbogen +8 more
TL;DR: Among several new ER-regulated genes, quinone reductase (QR), a detoxifying phase II antioxidant enzyme, is found that has its activity up-regulated by antiestrogens in an ER-dependent manner in breast cancer cells, thus showing 'reversed pharmacology'.
310
Antagonists selective for estrogen receptor α
Jun Sun,Ying R. Huang,William R. Harrington,Shubin Sheng,John A. Katzenellenbogen,Benita S. Katzenellenbogen +5 more
TL;DR: Basic side-chain substituents on various alkyl-triaryl-substituted pyrazoles were investigated, and the most ERα-selective compound was methyl-piperidino-pyrazole (MPP), which antagonizes E2 stimulation by ERα only.
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