Jun Min
4 Papers
3 Citations
Jun Min is an academic researcher. The author has contributed to research in topics: Internal medicine & Medicine. The author has an hindex of 1, co-authored 1 publications.
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Papers
Non-invasive early detection of cancer four years before conventional diagnosis using a blood test.
Xingdong Chen,Jeffrey A. Gole,Athurva Gore,He Qiye,Ming Lu,Ming Lu,Jun Min,Ziyu Yuan,Xiaorong Yang,Xiaorong Yang,Yanfeng Jiang,Tiejun Zhang,Chen Suo,Xiaojie Li,Lei Cheng,Zhenhua Zhang,Hongyu Niu,Zhe Li,Zhen Xie,Han Shi,Xiang Zhang,Min Fan,Xiaofeng Wang,Yajun Yang,Justin Dang,Catie McConnell,Juan Zhang,Jiucun Wang,Shun-Zhang Yu,Weimin Ye,Weimin Ye,Yuan Gao,Kun Zhang,Rui Liu,Li Jin +34 more
TL;DR: It is demonstrated that cancer can be non-invasively detected up to four years before current standard of care and patients whose disease is diagnosed in its early stages have better outcomes.
Development of a highly sensitive multicancer, targeted, cell-free DNA epigenomic assay for integrated screening of lung and colorectal cancer.
Anton Valouev,Elena Zotenko,Matthew W. Snyder,Charbel Eid,Jun Min,Yupeng He,Ariel Jaimovich,Haley D. Axelrod,Prashanthi Natarajan,Kathryn E. Pendleton,Anna Hartwig,Noam Vardi,Tam Banh,D. Kennedy,W. Greenleaf,Stefanie Mortimer,Sven Duenwald,Darya Chudova,AmirAli Talasaz +18 more
TL;DR: This blood-based multi-cancer screening assay that interrogates cell-free DNA methylation signatures for cancer detection and tissue of origin prediction in a set of tumor types where cancer screening can save lives yields clinically meaningful sensitivity and specificity for early-stage cancers.
4
Abstract 2141: Development of a highly-sensitive targeted cell-free DNA epigenomic assay for early-stage multi-cancer screening
Anton Valouev,Elena Zotenko,Matthew W. Snyder,Charbel Eid,Ngan Nguyen,Jun Min,Yupeng He,Ariel Jaimovich,Haley D. Axelrod,Prashanthi Natarajan,Anna Hartwig,Noam Vardi,Tam Banh,Andrew Kennedy,W. Greenleaf,Stefanie Mortimer,Sven Duenwald,Darya Chudova,AmirAli Talasaz +18 more
TL;DR: This multi-cancer targeted screening assay provides robust and sensitive detection of early-stage cancer at thresholds optimized for current screening paradigms with accurate tissue of origin identification.
2
Abstract 3758: Accurate epigenomic estimates of circulating tumor fraction in large-scale clinical data
William W. Greenwald,Yupeng He,Sai Chen,Tingting Jiang,Anton Valouev,Jun Min,Catalin Barbacioru,Daniel Gaile,Dustin Ma,Yvonne Kim,Giao Tran,I-Ping Wu,Ariel Jaimovich,Victoria M. Raymond,Rebecca Nagy,Han-Yu Chuang +15 more
TL;DR: It is demonstrated that epigenomic signatures accurately measure cTF using orthogonal analytes to somatic mutations and enable cTF estimation even in cases without detectable tumor driver variants, which may overcome the current limitations of somatic mutation based methods.