10 Papers
10 Citations
Jun Meng is an academic researcher from Lunenfeld-Tanenbaum Research Institute. The author has contributed to research in topics: Motor neuron & Biology. The author has an hindex of 4, co-authored 7 publications. Previous affiliations of Jun Meng include Hangzhou Normal University & University of Toronto.
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Papers
Myrf ER-Bound Transcription Factors Drive C. elegans Synaptic Plasticity via Cleavage-Dependent Nuclear Translocation
Jun Meng,Jun Meng,Xiaoxia Ma,Huaping Tao,Xia Jin,Daniel Witvliet,James R. Mitchell,Ming Zhu,Meng-Qiu Dong,Mei Zhen,Mei Zhen,Yishi Jin,Yingchuan B. Qi +12 more
TL;DR: MYRF-1 and MYRF-2, two C. elegans homologs of Myrf family transcription factors, are the first genes identified to be indispensable for promoting synaptic rewiring in C. elegans and reveal a molecular mechanism underlying synaptic reWiring and developmental circuit plasticity.
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Excitatory Motor Neurons are Local Central Pattern Generators in an Anatomically Compressed Motor Circuit for Reverse Locomotion [preprint]
Shangbang Gao,Sihui Asuka Guan,Anthony D. Fouad,Jun Meng,Yung-Chi Huang,Yi Li,Salvador Alcaire,Wesley Hung,Taizo Kawano,Yangning Lu,Yingchuan Billy Qi,Yishi Jin,Mark J. Alkema,Christopher Fang-Yen,Mei Zhen +14 more
TL;DR: It is shown that the cholinergic and excitatory class A motor neurons exhibit intrinsic and oscillatory activity, and such an activity can drive reverse locomotion without premotor interneurons.
A Neuroendocrine Modulation to Sustain C. elegans Forward Locomotion
Maria A. Lim,Jyothsna Chitturi,Valeriya Laskova,Jun Meng,Daniel Findeis,Anne Wiekenberg,Ben Mulcahy,Linjiao Luo,Yan Li,Yangning Lu,Wesley Hung,Yixin Qu,Chi-Yip Ho,Douglas Holmyard,Ni Ji,Rebecca WcWhirter,Aravinthan D. T. Samuel,David M. Miller,Ralf Schnabel,John A. Calarco,Mei Zhen +20 more
TL;DR: The role of a neuroendocrine cell RID in sustaining a specific behavioral state in C. elegans is established, and the Six/SO-family homeobox transcription factor UNC-39 governs lineage-specific neurogenesis to give rise to a neuron RID.
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K2P channel TWK-40 Regulates a Rhythmic Behavior in C. elegans
Zhongpu Yue,Yongning Zhang,Bin Yu,Yueqing Xu,Lili Chen,Yi Li,Jyothsna Chitturi,Jun Meng,W. Huang,Thomas Boulin,Mei Zhen,Shangbang Gao +11 more
TL;DR: It is shown here a K2P TWK-40 regulates the rhythmic defecation motor program (DMP) in Caenorhabditis elegans, and an essential inhibitor of DMP is demonstrated, thus revealing a cellular mechanism by funtional K1P channel of rhythmic motor activity.
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A descending interneuron with depolarized resting membrane potential controls C. elegans motor states
Jun Meng,Tosif Ahamed,Bin Yu,W. Huang,Sonia El Mouridi,Alice Leclercq-Blondel,Marie Gendrel,Zezhen Wang,Lili Chen,Quan Wen,Thomas Boulin,Shangbang Gao,Mei Zhen +12 more
TL;DR: It is proposed that a single neuron can regulate the activity of motor circuits generating two mutually exclusive behaviors, finding that phasic optogenetic activation of AVA leads to backward locomotion, while tonic optogensetic activation potentiates forward locomotion.
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