Jun Long
University of Miami
25 Papers
117 Citations
Jun Long is an academic researcher from University of Miami. The author has contributed to research in topics: Smoothened & Sonic hedgehog. The author has an hindex of 11, co-authored 20 publications.
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Papers
The BET Bromodomain Inhibitor I-BET151 Acts Downstream of Smoothened Protein to Abrogate the Growth of Hedgehog Protein-driven Cancers
Jun Long,Bin Li,Jezabel Rodriguez-Blanco,Chiara Pastori,Claude-Henry Volmar,Claes Wahlestedt,Anthony J. Capobianco,Feng Bai,Xin Hai Pei,Nagi G. Ayad,David J. Robbins +10 more
TL;DR: It is suggested that BET protein modulation may be an attractive therapeutic strategy for attenuating the growth of HH-dependent cancers, such as medulloblastoma.
118
Hedgehog Signaling Regulates Bladder Cancer Growth And Tumorigenicity
Dennis Liang Fei,Dennis Liang Fei,Dennis Liang Fei,Avencia Sanchez-Mejias,Zhiqiang Wang,Colin A. Flaveny,Jun Long,Samer Singh,Jezabel Rodriguez-Blanco,Robert Tokhunts,Robert Tokhunts,Camilla Giambelli,Karoline J. Briegel,Wolfgang A. Schulz,A. Jay Gandolfi,Margaret R. Karagas,Teresa A. Zimmers,Teresa A. Zimmers,Merce Jorda,Pablo A. Bejarano,Anthony J. Capobianco,David J. Robbins +21 more
TL;DR: Surprisingly, rather than originating from loss of PTCH1, the constitutive HH activity observed in urothelial carcinoma cell lines was HH ligand dependent.
53
The Hedgehog processing pathway is required for NSCLC growth and survival
Jezabel Rodriguez-Blanco,Neal S. Schilling,Neal S. Schilling,Robert Tokhunts,Robert Tokhunts,Camilla Giambelli,Jun Long,D. Liang Fei,D. Liang Fei,Samer Singh,Kendall E. Black,Zhiqiang Wang,Fabrizio Galimberti,Pablo A. Bejarano,S. Elliot,Marilyn K. Glassberg,Dao M. Nguyen,William W. Lockwood,Wan L. Lam,Ethan Dmitrovsky,Anthony J. Capobianco,David J. Robbins +21 more
TL;DR: It is demonstrated that HH-dependent non-small cell lung carcinoma (NSCLC) growth is sensitive to blockade of the HH pathway upstream of SMO, at the level of HH ligand processing, and a critical role for HH processing in HH- dependent tumors is shown.
42
Identification of a family of fatty-acid-speciated sonic hedgehog proteins, whose members display differential biological properties.
Jun Long,Robert Tokhunts,Robert Tokhunts,William M. Old,Stephane Houel,Jezabel Rodgriguez-Blanco,Samer Singh,Neal S. Schilling,Neal S. Schilling,Anthony J. Capobianco,Natalie G. Ahn,Natalie G. Ahn,David J. Robbins +12 more
TL;DR: The purified Sonic Hedgehog (SHH) from cells expressing physiologically relevant levels was purified and showed that it was more potent than SHH isolated from overexpressing cells, and the fatty acid composition of SHH affected its trafficking to lipid rafts as well as its potency.
32
Time series modeling of cell cycle exit identifies Brd4 dependent regulation of cerebellar neurogenesis.
Clara Penas,Clara Penas,Marie E. Maloof,Vasileios Stathias,Jun Long,Sze Kiat Tan,Jose Mier,Yin Fang,Camilo Valdes,Jezabel Rodriguez-Blanco,Cheng Ming Chiang,David J. Robbins,Daniel J. Liebl,Jae K. Lee,Mary E. Hatten,Jennifer Clarke,Nagi G. Ayad +16 more
TL;DR: RNA-sequencing of GCPs exiting the cell cycle was performed to identify downregulation of Brd4 activity as an early event during cell cycle exit which subsequently regulates Shh activity and is needed for proper cerebellar development.