Jun-Ling Chen
Donghua University
5 Papers
42 Citations
Jun-Ling Chen is an academic researcher from Donghua University. The author has contributed to research in topics: Total synthesis & Trifluoromethylation. The author has an hindex of 4, co-authored 5 publications.
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Papers
Synthesis of γ-monofluorinated goniothalamin analogues via regio- and stereoselective ring-opening hydrofluorination of epoxide.
TL;DR: A stereoselective synthesis of the biologically interesting γ-monofluorinated goniothalamin analogue 2a was described and the chiral hydroxypropynyl fluorohydrin 15 was used as a valuable building block for preparation of a range of α,β-unsaturated δ-lactones.
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4-CF3-ezetimibe analogs: design, synthesis, and biological evaluation of cholesterol absorption inhibitions
TL;DR: In this paper, trifluoromethyl substituted ezetimibe analogs 1a-d were designed and synthesized for the purpose of looking for better cholesterol absorption inhibitors.
18
Total synthesis of the trifluoromethylated analog of isoaltholactone: 5-trifluoromethylisoaltholactone
TL;DR: The first fluorine-containing analog of iso-altholactone, 5-trifluoromethyliso-altholine, was synthesized in this article.
13
Total synthesis of γ-trifluoromethylated analogs of goniothalamin and their derivatives
TL;DR: An efficient method for the construction of chiral gamma-trifluoromethylated alpha,beta-unsaturated delta-lactone, a widely existing pharmacophore, has been developed and successfully applied for synthesis of gamma- TrfL/goniothalamins.
10
Total Synthesis of the Trifluoromethylated Analogue of Isoaltholactone: 5-Trifluoromethylisoaltholactone.
TL;DR: The first fluorine-containing analog of iso-altholactone, 5-trifluoromethyliso-altholine (I), was synthesized in this article.