6 Papers
22 Citations
Jun Ju is an academic researcher from University of Texas Dental Branch at Houston. The author has contributed to research in topics: Porphyromonas gingivalis & Osteoblast. The author has an hindex of 6, co-authored 6 publications. Previous affiliations of Jun Ju include University of Texas at Austin.
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Papers
Porphyromonas gingivalis infection increases osteoclastic bone resorption and osteoblastic bone formation in a periodontitis mouse model.
TL;DR: Although P. gingivalis appears to suppress osteoblast pool and enhance osteoclastic bone resorption, the bone formation capacity is temporarily elevated in the infected mice, possibly via some anti-microbial compensational mechanisms.
Fimbriae of Porphyromonas gingivalis are important for initial invasion of osteoblasts, but not for inhibition of their differentiation and mineralization.
TL;DR: It is revealed that major fimbriae are involved in the initial invasion of osteoblasts by P. gingivalis, but are not essential for the subsequent inhibition of osteoblast differentiation and mineralization in long-term culture.
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Odontoblast-targeted Bcl-2 overexpression promotes dentine damage repair.
Wenjian Zhang,Jun Ju +1 more
TL;DR: B cl-2 overexpression prevents odontoblast apoptosis and promotes dentine damage repair, indicating that genetic manipulation of Bcl-2 may be a novel strategy to maintain the vitality and function of dentine-pulp complex under detrimental mechanical stimuli.
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Odontoblast-targeted Bcl-2 Overexpression Impairs Dentin Formation
TL;DR: Some novel functions of Bcl‐2 in dentinogenesis in addition to its anti‐apoptotic effect are revealed, which shed some light on the genetic complexity of tooth development.
Integrin α5β1-fimbriae binding and actin rearrangement are essential for Porphyromonas gingivalis invasion of osteoblasts and subsequent activation of the JNK pathway
TL;DR: In vitro observations indicate that P. gingivalis manipulates osteoblast function to promote its initial intracellular persistence by prolonging the host cell life span prior to its intercellular dissemination via host cell lysis.