Jun Joelle Wang
Southern University of Science and Technology
8 Papers
36 Citations
Jun Joelle Wang is an academic researcher from Southern University of Science and Technology. The author has contributed to research in topics: Enantioselective synthesis & Atom economy. The author has an hindex of 7, co-authored 8 publications. Previous affiliations of Jun Joelle Wang include Hong Kong Baptist University.
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Papers
Asymmetric phosphoric acid–catalyzed four-component Ugi reaction
Jian Zhang,Peiyuan Yu,Shaoyu Li,He Sun,Shao-Hua Xiang,Jun Joelle Wang,Kendall N. Houk,Bin Tan +7 more
TL;DR: It is shown that chiral phosphoric acids can catalyze the four-component coupling with high enantioselectivity and be targeted as a catalyst for asymmetric Ugi-4CR, well suited for diversity-oriented synthesis applicable in drug discovery.
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Phosphoric acid-catalyzed atroposelective construction of axially chiral arylpyrroles
TL;DR: The atroposelective synthesis of axially chiral arylpyrrole derivatives proved to be efficient chiral ligands for asymmetric catalysis, through desymmetrization and kinetic resolution.
Palladium-catalyzed asymmetric hydrophosphorylation of alkynes: facile access to P-stereogenic phosphinates
TL;DR: A catalytic enantioselective method for the synthesis of P-stereogenic alkenylphosphinates is developed through asymmetric hydrophosphorylation of alkynes, and this process is demonstrated for a wide range of racemic phosphinates.
Cobalt-Catalyzed Direct C–H Thiolation of Aromatic Amides with Disulfides: Application to the Synthesis of Quetiapine
Mingliang Li,Jun Joelle Wang +1 more
TL;DR: A mechanistic study indicates that the cobalt(IV) intermediate is probably formed during the course of the reaction, which can be transformed to Quetiapine, which is an atypical antipsychotic agent approved for the treatment of schizophrenia and bipolar disorder.
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Catalytic asymmetric trifluoromethylthiolation of carbonyl compounds via a diastereo and enantioselective Cu-catalyzed tandem reaction
TL;DR: A diastereo and enantioselective Cu-catalyzed tandem 1,4-addition/trifluoromethylthiolation of acyclic enones is described, enabling the asymmetric integration of the -SCF3 group to carbonyl compounds and establishing chiral tertiary α-carbon centers.
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