Jun Jiang
Chinese Academy of Sciences
8 Papers
104 Citations
Jun Jiang is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Gene & Interferon. The author has an hindex of 8, co-authored 8 publications.
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Papers
The innate immune response to grass carp hemorrhagic virus (GCHV) in cultured Carassius auratus blastulae (CAB) cells.
TL;DR: Strong evidence is provided for existence of IFN antiviral innate immune response in fish, and the IFN response contributes to the formation of an antiviral state probably through JAK-STAT signaling pathway.
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Molecular characterization and subcellular localization of Carassius auratus interferon regulatory factor-1.
TL;DR: Subcellular localization analysis confirms the nuclear distribution of CaIRF-1 protein, and reveals two nuclear localization signals (NLS), any one of which is sufficient for nuclear translocation of Cairf-1, which is revealed as a new nuclear localization motif in the DBD of a vertebrate IRF- 1.
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Expression regulation and functional characterization of a novel interferon inducible gene Gig2 and its promoter
TL;DR: The Gig2 promoter-driven construct is highly induced in CAB cells after treatment with Poly I:C or rIFN, and the functional capability is dependent on IFN regulatory factor 7 (IRF7), because its activity can be stimulated by IRF7.
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Gig1, a novel antiviral effector involved in fish interferon response.
TL;DR: It is reported that grass carp reovirus-induced gene 1 (Gig1) was a typical fish ISG, and Gig1 homologs were found exclusively in fish species forming a novel gene family, illustrating that there exists a Gig1 gene family unique to fish species and the founding gene mediates a novel fish IFN antiviral pathway.
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Inductive expression and characterization analysis of Paralichthys olivaceus pigment epithelium-derived factor in a virally infected cell line
Yu-Dong Chen,Yi-Bing Zhang,Rong Zhu,Fu-Tie Zhang,Jun Jiang,Yan Shi,Qi-Ya Zhang,Song-Lin Chen,Jian-Fang Gui +8 more
TL;DR: This is the first report on the transcriptional induction of PEDF in virally infected cells and it was confirmed that fish PEDFs and mammalian members formed a well-supported clade.
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