Poly(butylene succinate)-based polyesters for biomedical applications: A review

Electrospinning of food proteins and polysaccharides

Recent advances in multiaxial electrospinning for drug delivery

Electrospinning is considered a promising technology for fabricating ultrafine fibers via the application of electrostatic repulsive forces Electrospun nanofibers produced via emulsion electrospinning are widely used as delivery systems to encapsulate bioactive compounds and drugs in food and pharmaceuticals, respectively Emulsion electrospinning has also gained significant interest for the production of vehicles for sustained and controlled release There are several parameters affecting the properties of fabricated fibers including the type of emulsion, emulsion composition, electric field strength, conductivity of solution, surface tension, electrode configuration, solution cooling time, dissolution temperature, and solution flow rate; therefore, all these parameters should be precisely controlled to obtain optimum results Some of the advantages of these fibers are the protection of encapsulated materials from environmental conditions, room temperature processes, release rate control and high loading efficiency This study presents an overview of the emulsion electrospinning method, its mechanism of action and its applications in both the food and pharmaceutical fields

/pdf/emulsion-based-systems-for-fabrication-of-electrospun-43gn6v040b.pdf

Emulsion-based systems for fabrication of electrospun nanofibers: food, pharmaceutical and biomedical applications

Polymeric nanofibers (NFs) have been extensively reported as a biocompatible scaffold to be specifically applied in several researching fields, including biomedical applications. The principal researching lines cover the encapsulation of antitumor drugs for controlled drug delivery applications, scaffolds structures for tissue engineering and regenerative medicine, as well as magnetic or plasmonic hyperthermia to be applied in the reduction of cancer tumors. This makes NFs useful as therapeutic implantable patches or mats to be implemented in numerous biomedical researching fields. In this context, several biocompatible polymers with excellent biocompatibility and biodegradability including poly lactic-co-glycolic acid (PLGA), poly butylcyanoacrylate (PBCA), poly ethylenglycol (PEG), poly (e-caprolactone) (PCL) or poly lactic acid (PLA) have been widely used for the synthesis of NFs using the electrospun technique. Indeed, other types of polymers with stimuli-responsive capabilities has have recently reported for the fabrication of polymeric NFs scaffolds with relevant biomedical applications. Importantly, colloidal nanoparticles used as nanocarriers and non-biodegradable structures have been also incorporated by electrospinning into polymeric NFs for drug delivery applications and cancer treatments. In this review, we focus on the incorporation of drugs into polymeric NFs for drug delivery and cancer treatment applications. However, the principal novelty compared with previously reported publications is that we also focus on recent investigations concerning new strategies that increase drug delivery and cancer treatments efficiencies, such as the incorporation of colloidal nanoparticles into polymeric NFs, the possibility to fabricate NFs with the capability to respond to external environments, and finally, the synthesis of hybrid polymeric NFs containing carbon nanotubes, magnetic and gold nanoparticles, with magnetic and plasmonic hyperthermia applicability.

https://www.mdpi.com/2079-4991/9/4/656/pdf

Electrospun Nanofibers: Recent Applications in Drug Delivery and Cancer Therapy.

Novel biocompatible poly(lactide-co-glycolide) (PLGA) nanofiber mats with favorable biocompatibility and good mechanical strength were prepared, which could serve as an innovative type of tissue engineering scaffold or an ideal controllable drug delivery system. Both hydrophobic and hydrophilic drugs, Cefradine and 5-fluorouracil were successfully loaded into PLGA nanofiber mats by emulsion electrospinning. The natural bioactive protein gelatin (GE) was incorporated into the nanofiber mats to improve the surface properties of the materials for cell adhesion. Nanofibrous scaffolds were characterized by scanning electron microscopy, X-ray diffraction, differential scanning calorimetry, contact angle and tensile measurements. Emulsion electrospun fibers with GE had perfect hydrophilic and good mechanical property. The in vitro release test showed thedrugs released from emulsion electrospun fibers, which achieved lower burst release. The cells cytotoxicity experiment indicated that emulsion electrospun fibers were less toxic and tended to promote fibroblasts cells attachment and proliferation, which implied that the electrospun fibers had promising potential application in tissue engineering or drug delivery.

Preparation and characterization of electrospun PLGA/gelatin nanofibers as a drug delivery system by emulsion electrospinning

This research described a novel composite electrospun nanofibers, which were consisted of MPEG-b-PLA micelles, chitosan, and PEO, realizing controlled release of both hydrophobic and hydrophilic drugs. 5-FU and Cefradine used as model drugs were successfully loaded in the nanofibers. The in vitro studies showed there was a low initial burst release of 5-FU from micelles-loaded nanofibers, and the final release proportion was about 91.4% after continually releasing for 109 h. In vitro cytotoxicity studies revealed that 5-FU-loaded nanofibers restrained HepG-2 cells efficiently, and the cell viability was 45.9% after three days of cultivation in solutions containing micelles-loaded nanofibers with 21.6 μg 5-FU. All results suggested that micelles-loaded nanofibers with two kinds of drugs can be used as an effective controlled drug delivery vehicle and may have a bright future in cancer chemotherapy or clinical treatments.

Novel controlled drug delivery system for multiple drugs based on electrospun nanofibers containing nanomicelles

Crystallization and degradation behaviors of poly(butylene succinate)/poly(Z-l-lysine) composites

Multiple drugs-loaded electrospun composite nanofibrous scaffolds have attracted much interest as drug delivery vehicles for the treatment of tissue defect after tumor resection In this study, a novel mesoporous ZnO/poly(lactic-co-glycolic acid)/gelatin (mZnO/PLGA/GE) electrospun composite fiber encapsulated with both hydrophilic drug (doxorubicin hydrochloride, DOX) and hydrophobic drug (camptothecin, CPT) is fabricated mZnO is firstly used to encapsulate DOX Then, the DOX-loaded mZnO (DOX@mZnO) and CPT were mixed with PLGA/GE solution to fabricate electrospun hybrid nanofibers The in vitro release results demonstrated that the CPT in the composite fibers presented a fast release, while DOX showed a sustained release behavior The cell cytotoxicity test indicated that the composite nanofiber with two drugs showed strong antitumor efficacy against HepG-2 cells Moreover, the addition of GE increased the hydrophilicity of the composite fibers More importantly, the incorporated of mZnO within the PLGA/GE nanofibers cannot only significantly reduce the burst release of DOX, but also improve the mechanical durability of the composite nanofibers Thus, the composite nanofibers could be a versatile drug delivery system encapsulated with both hydrophilic and hydrophobic anticancer drugs as implantable scaffolds for potential postsurgical cancer treatment

Multiple drug-loaded electrospun PLGA/gelatin composite nanofibers encapsulated with mesoporous ZnO nanospheres for potential postsurgical cancer treatment

Handle everyday research tasks with reliable, citation-backed results

Your personal Research Agent to handle research tasks with citation-backed results

Popular Tasks used by Researchers

How can I help with your research?

Meet SciSpace

Get more enhanced response by uploading the PDFs you want me to reference.

No relevant PDFs in your library

SciSpace is the AI research assistant for academics. Run systematic literature reviews on 280M+ papers, and write papers with cited sources. Trusted by 1M+ students, PhDs & researchers.

SciSpace | AI for Research

Analyze PDFs

Code & Manuscripts

Funding & Grants

Literature & Patents

Medical & Clinical Data

Systematic Review

Visualize & Present

Web & Data

Build a Google Scholar-like website for your research.

Build a website

Create charts and images for your research

Create a Chart

Write a paper for submission to a journal

Draft a manuscript

Patent Search

Design eye-catching scientific posters in minutes.

Scientific Poster Generation

Systematic Literature Review

One task is running at the moment. Your messages will be shown right after.

Drag and drop or click here to browse

Loved by <highlight>1 million+</highlight> researchers

Extract a list of specific topics and their sources from unstructured text

Topics

Compare and analyze relevant papers that matches with your search

Papers

Get insights from PDFs and bookmarked papers from your library

My library

Recent searches

Try searching for:

Catch AI-generated content in scholarly and non-scholarly content

{ai} Detector

Ai Writer

Get PDF Summaries, highlighted text explanations 

Chat with PDF

Effortlessly create in-text citations and bibliographies in APA and 2,500 other formats

Citation generator

Get explanations, summaries, and answers on academic papers

Ease up your research workflow with {scispace}'s cohort of exciting AI tools

Elevate your academic writing skills and convey your ideas the way you want

Paraphraser

Explore our range of reading and writing tools

Your file is being prepared and should be ready in a few minutes. If it's a large file, it might take a bit longer. You can close this window, and we'll email you the file when it's done.

You have reached a maximum limit of <strong>{limit}</strong> columns in the table. Remove at least <strong>1</strong> column to add or create another one.

Jun Hu

Author Tools

Chat about Author

Papers

Preparation and characterization of electrospun PLGA/gelatin nanofibers as a drug delivery system by emulsion electrospinning

Novel controlled drug delivery system for multiple drugs based on electrospun nanofibers containing nanomicelles

Crystallization and degradation behaviors of poly(butylene succinate)/poly(Z-l-lysine) composites

Multiple drug-loaded electrospun PLGA/gelatin composite nanofibers encapsulated with mesoporous ZnO nanospheres for potential postsurgical cancer treatment