37 Papers
78 Citations
Jun Hu is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Chemistry & Berberine. The author has an hindex of 15, co-authored 35 publications. Previous affiliations of Jun Hu include Tsinghua University.
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Papers
Tbx20 acts upstream of Wnt signaling to regulate endocardial cushion formation and valve remodeling during mouse cardiogenesis
Xiaoqiang Cai,Weijia Zhang,Jun Hu,Lu Zhang,Nishat Sultana,Bingruo Wu,Weibin Cai,Bin Zhou,Chen-Leng Cai +8 more
TL;DR: The study suggests a model in which Tbx20 regulates the Wnt pathway to direct endocardial cushion maturation and valve elongation, and provides new insights into the etiology of valve defects in humans.
PI3K p55γ promoter activity enhancement is involved in the anti-apoptotic effect of berberine against cerebral ischemia-reperfusion.
Jun Hu,Yu-Shuang Chai,Yugang Wang,Michael M. Kheir,Michael M. Kheir,Huiying Li,Zhi-Yi Yuan,Hong-Jiao Wan,Dongming Xing,Fan Lei,Li-Jun Du +10 more
TL;DR: It is found that the anti-apoptotic effects of berberine against ischemia were indeed mediated by the increased phosphor-activation of Akt (higher p-Akt to total Akt), leading to the intensified phosphorylation of Bad and the decreased cleavage of the pro-APoptotic protease caspase-3.
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Comprehensive study in the inhibitory effect of berberine on gene transcription, including TATA box.
Yugang Wang,Michael M. Kheir,Michael M. Kheir,Yu-Shuang Chai,Jun Hu,Dongming Xing,Fan Lei,Lijun Du +7 more
TL;DR: It is hypothesized that berberine can suppress the transcription of DNA in living cell systems, especially suppressing the association between TBP and the TATA box by binding with DNA and, thus, inhibiting TATAbox-dependent gene expression in a non-specific way.
Antioxidant activity in vitro of three constituents from caesalpinia sappan L
TL;DR: In this paper, the 95% ethanol extract from Caesalpinia sappan heartwood (ECS), protosappanin A, protosappa-carbinin B, and brazilein were studied in vitro for the inhibition of the formation of malondialdehyde and the scavenging of superoxide anions, hydrogen peroxide, and hydroxyl radicals.
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Comprehensive study of baicalin down-regulating NOD2 receptor expression of neurons with oxygen-glucose deprivation in vitro and cerebral ischemia-reperfusion in vivo.
TL;DR: Data demonstrated that targeting on NOD2 especially in neurons directly was possibly attributed to the neural-protective effect of baicalin in the injury of cerebral ischemia-reperfusion.
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