Jun Guo
Shandong University
5 Papers
4 Citations
Jun Guo is an academic researcher from Shandong University. The author has contributed to research in topics: Signal transduction & PI3K/AKT/mTOR pathway. The author has an hindex of 4, co-authored 5 publications.
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Papers
Presence of thyrotropin receptor in hepatocytes: not a case of illegitimate transcription
TL;DR: Examination of the expression of TSHR in human and rat liver tissues, as well as human normal hepatocyte cell line L‐02, shows that T SHR is present and functional in hepatocytes, and this expression is not a case of illegitimate transcription.
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Characterization of a Relatively Malignant form of Osteopetrosis Caused by a Novel Mutation in the PLEKHM1 Gene
Tao Bo,Fang Yan,Jun Guo,Xiaoyan Lin,Haiqing Zhang,Qingbo Guan,Hai Wang,Li Fang,Ling Gao,Jiajun Zhao,Chao Xu +10 more
TL;DR: A four‐year follow‐up study of the patient showed that the PLEKHM1‐dependent osteopetrosis was relatively malignant, with significant symptoms of pancytopenia and hepatosplenomegaly.
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Insulin-like growth factor-1 promotes cell cycle progression via upregulation of cyclin D1 expression through the phosphatidylinositol 3-kinase/nuclear factor-κB signaling pathway in FRTL thyroid cells
Meng Ren,Xia Zhong,Chunyan Ma,Ying Sun,Qingbo Guan,Bin Cui,Jun Guo,Hai Wang,Ling Gao,Jiajun Zhao +9 more
TL;DR: The results of the present study show that in FRTL cells, IGF-1 promotes cell cycle progression via an upregulation of cyclin D1 expression, at least partially through the PI3K/NF-κB signaling pathway.
Phosphatidylinositol 3-kinase/nuclear factor-κB signaling pathway is involved in the regulation of IGF-I on Fas-associated death domain-like interleukin-1-converting enzyme-inhibitory protein expression in cultured FRTL thyroid cells
Meng Ren,Qingbo Guan,Xia Zhong,Bendi Gong,Ying Sun,Wei Xin,Jun Guo,Hai Wang,Ling Gao,Jiajun Zhao +9 more
TL;DR: Investigating mRNA and protein levels of an antiapoptotic protein, namely, Fas-associated death domain-like interleukin-1-converting enzyme (FLICE)-inhibitory protein (FLIP), suggested that IGF-I regulates the expression of FLIP in FRTL cells by activating the PI3K/NF-kappaB cascade.
Clinical and genetic characteristics of Gitelman syndrome in 5 pedigrees
Ranran Shi,Congcong Li,Li Fang,Jin Xu,Qingbo Guan,Xinli Zhou,Jun Guo,Wenxia Han,Qing Chen,Li Feng,Jiajun Zhao,Chao Xu +11 more
TL;DR: Six heterozygous SLC12A3 gene mutations are the major cause of the five pedigrees of Gitelman syndrome, and these mutations were predicted to change the normal protein structure.
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