4 Papers
Jun Gao is an academic researcher from Los Alamos National Laboratory. The author has contributed to research in topics: Surface modification & Ubiquitin ligase. The author has an hindex of 3, co-authored 4 publications.
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Papers
Comprehensive analysis of the effects of CdSe quantum dot size, surface charge, and functionalization on primary human lung cells.
TL;DR: QD charge and ligand length, and to a lesser extent, size, are key factors that should be considered when engineering nanomaterials with minimal bioimpact (charge > functionalization > size).
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Fullerene derivatives induce premature senescence: a new toxicity paradigm or novel biomedical applications.
TL;DR: The discovery of premature senescence as a potential endpoint of nanomaterial elicited biological effects is reported, for the first time, providing a new paradigm for nanoparticle-induced toxicity in human cells.
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Suppression of proinflammatory cytokines in functionalized fullerene-exposed dermal keratinocytes
TL;DR: The results indicate that tris-C60 (size range <100 nm) significantly reduces inflammatory cytokine release in a dose- and time-dependent manner, while CD-C 60 demonstrated a relatively pro-inflammatory cytokine response, while hexa-C50 did not significantly perturb cytokine responses.
Modulation of g-Irradiation Induced ROS Responses by Engineered Fullerenes in Human Epidermal Keratinocytes
Jun Gao,Hsing-Lin Wang,Andrew P. Shreve,Rashi Iyer +3 more
- 01 Jun 2008
TL;DR: The results point to the potential use of fullerene derivatives as novel therapeutic agents for protection against high-dose irradiation generated ROS-induced cellular damage.