105 Papers
522 Citations
Jun Asai is an academic researcher from Kyoto Prefectural University of Medicine. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 22, co-authored 92 publications. Previous affiliations of Jun Asai include Tufts University.
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Papers
Netrins Promote Developmental and Therapeutic Angiogenesis
Brent D. Wilson,Masaaki,Kye Won Park,Arminda Suli,Lise K. Sorensen,Frederic Larrieu-Lahargue,Lisa D. Urness,Wonhee Suh,Jun Asai,Gerhardus A H Kock,Tina Thorne,Marcy Silver,Kirk R. Thomas,Chi Bin Chien,Douglas W. Losordo,Dean Y. Li +15 more
TL;DR: It is shown that netrins accelerate neovascularization in an in vivo model of ischemia and that they reverse neuropathy and vasculopathy in a diabetic murine model, suggesting a proangiogenic role forNetrins during vertebrate development.
Endothelial Progenitor Thrombospondin-1 Mediates Diabetes-Induced Delay in Reendothelialization Following Arterial Injury
Masaaki,Hideya Takenaka,Jun Asai,Jun Asai,Kayoko Ibusuki,Yusuke Mizukami,Kazuichi Maruyama,Young Sup Yoon,Andrea Wecker,Corinne Luedemann,Elizabeth Eaton,Marcy Silver,Tina Thorne,Douglas W. Losordo,Douglas W. Losordo +14 more
TL;DR: Diabetic EPCs have phenotypic differences involving thrombospondin-1 expression compared with nondiabetic E PCs, revealing potential novel mechanistic insights and therapeutic targets to improve reendothelialization and reduce restenosis in diabetes.
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Estrogen Receptors α and β Mediate Contribution of Bone Marrow–Derived Endothelial Progenitor Cells to Functional Recovery After Myocardial Infarction
Hiromichi Hamada,Myeong Kon Kim,Atsushi Iwakura,Masaaki,Tina Thorne,Gangjian Qin,Jun Asai,Yoshiaki Tsutsumi,Haruki Sekiguchi,Marcy Silver,Andrea Wecker,Evelyn Bord,Yan Zhu,Raj Kishore,Douglas W. Losordo +14 more
TL;DR: Both ER&agr; and ER&bgr; contribute to E2-mediated EPC activation and tissue incorporation and to preservation of cardiac function after myocardial infarction.
170
Podoplanin: An emerging cancer biomarker and therapeutic target.
Harini Krishnan,Julie Rayes,Tomoyuki Miyashita,Genichiro Ishii,Edward P. Retzbach,Stephanie A. Sheehan,Ai Takemoto,Yao Wen Chang,Kazue Yoneda,Jun Asai,Lasse Jensen,Lushun Chalise,Atsushi Natsume,Gary S. Goldberg +13 more
TL;DR: This review describes recent advances in how PDPN may be used as a biomarker and therapeutic target for many types of cancer, including glioma, squamous cell carcinoma, mesothelioma and melanoma.
IL-10-induced TNF-alpha mRNA destabilization is mediated via IL-10 suppression of p38 MAP kinase activation and inhibition of HuR expression
Johnson Rajasingh,Evelyn Bord,Corinne Luedemann,Jun Asai,Hiromichi Hamada,Tina Thorne,Gangjian Qin,David A. Goukassian,Yan Zhu,Douglas W. Losordo,Raj Kishore +10 more
TL;DR: Systemic IL‐10 treatment after carotid artery denudation in mice blunts inflammatory cell infiltration and arterial tumor necrosis factor (TNF) expression and may provide insights necessary to develop strategies for modulating vascular repair and other accelerated arteriopathies, including transplant vasculopathy and vein graft hyperplasia.
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