Jun Agata
Sapporo Medical University
13 Papers
213 Citations
Jun Agata is an academic researcher from Sapporo Medical University. The author has contributed to research in topics: Insulin resistance & Glucose clamp technique. The author has an hindex of 9, co-authored 13 publications.
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Papers
Olmesartan Is an Angiotensin II Receptor Blocker with an Inhibitory Effect on Angiotensin-Converting Enzyme
Jun Agata,Nobuyuki Ura,Hideaki Yoshida,Yasuyuki Shinshi,Haruki Sasaki,Masaya Hyakkoku,Shinya Taniguchi,Kazuaki Shimamoto +7 more
TL;DR: It is suggested that olmesartan may exhibit an ACE inhibitory action in addition to an Ang II receptor blocking action, prevent an increase in Ang II level, and protect cardiovascular remodeling through an increased in cardiac nitric oxide production and endogenous Ang-(1-7) via over-expression of ACE2.
Angiotensin II receptor blocker prevents increased arterial stiffness in patients with essential hypertension.
Jun Agata,Daigo Nagahara,Shuichi Kinoshita,Yoshitoki Takagawa,Norihito Moniwa,Daisuke Yoshida,Nobuyuki Ura,Kazuaki Shimamoto +7 more
TL;DR: Long-term treatment with ARB inhibits the progression of arterial stiffness independent of BP reduction, and one of the mechanisms may be related to the increased serum adiponectin concentration after treatment with an ARB.
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Alteration of muscle fiber composition linking to insulin resistance and hypertension in fructose-fed rats.
Katsuhiro Higashiura,Nobuyuki Ura,Tamaki Takada,Jun Agata,Hideaki Yoshida,Yoshinori Miyazaki,Kazuaki Shimamoto +6 more
TL;DR: It is suggested that fiber composition of skeletal muscle links insulin resistance and that a calcium channel antagonist may modulate muscle fiber composition in hypertensive animal model, fructose-fed rats.
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Role of hyperinsulinemia in atherosclerotic coronary arterial disease: studies of semi-quantitative coronary angiography.
Kazufumi Tsuchihashi,Nobuichi Hikita,Mamoru Hase,Jun Agata,Shigeyuki Saitoh,Tomoaki Nakata,Nobuyuki Ura,Kazuaki Shimamoto +7 more
TL;DR: It is suggested that hyperinsulinemia is a risk for coronary arterial disease, and emphasize the severity of coronary atherosclerosis in normal glucose tolerant subjects.
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Renal Protective Role of Bradykinin B1 Receptor in Stroke-Prone Spontaneously Hypertensive Rats
Makoto Hagiwara,Hideyuki Murakami,Nobuyuki Ura,Jun Agata,Hideaki Yoshida,Katsuhiro Higashiura,Kazuaki Shimamoto +6 more
TL;DR: The results indicated that renal B1R might be over-expressed in a high blood pressure condition, and that this upregulated B1 R may play an important role in renal protection by inhibiting renal fibrosis via an increase of NO production and a suppression of TGFbeta1 expression and mitogen-activated protein kinase (ERK and p38) phosphorylation.
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