A suplementacao de creatina vem sendo utilizada amplamente na tentativa de aumentar forca e massa magra em sujeitos saudaveis e atletas. Alem disso, diversos estudos tem sido conduzidos no intuito de desvendar os mecanismos responsaveis pelas eventuais adaptacoes a esse suplemento. Diante disso, essa revisao teve como objetivos: 1) discutir os principais estudos que investigaram os efeitos da suplementacao de creatina na forca e hipertrofia; e 2) reunir as evidencias acerca dos possiveis mecanismos responsaveis pelo aumento de forca e massa magra como consequencia desse suplemento, enfatizando os mais recentes achados e as perspectivas sobre o tema. De fato, existem fortes evidencias demonstrando que a suplementacao de creatina e capaz de promover aumentos de forca e hipertrofia. Os efeitos desse suplemento sobre a retencao hidrica, o balanco proteico, a expressao de genes/proteinas associados a hipertrofia e ativacao de celulas satelites, podem explicar as adaptacoes musculoesqueleticas observadas. Diante desses achados, os potenciais efeitos terapeuticos desse suplemento emergem como um futuro e promissor campo de estudo.

/pdf/efeitos-da-suplementacao-de-creatina-sobre-forca-e-4iguffo6rv.pdf

Efeitos da suplementação de creatina sobre força e hipertrofia muscular: atualizações

The objective of this study was to analyze the effect of supplementation with creatine and glutamine on physical fitness of military police officers. Therefore, an experimental double blind study was developed, with the final sample composed by 32 men randomly distributed into three groups: a group supplemented with creatine (n=10), glutamine (n=10) and a placebo group (n=12) and evaluated in three distinct moments, in an interval of three months (T1, T2 and T3). The physical training had a weekly frequency of 5 sessions × 90 min, including strength exercises, local muscular resistance, flexibility and both aerobic and anaerobic capacity. After analyzing the effect of time, group and interaction (group × time) for measures that indicated the physical capabilities of the subjects, a significant effect of time for the entire variable was identified (p 0,05). In face of the results it was concluded that supplementation with creatine and glutamine showed no ergogenic effect on physical performance in military police officers.

/pdf/is-long-term-creatine-and-glutamine-supplementation-565rqy385y.pdf

Is Long Term Creatine and Glutamine Supplementation Effective in Enhancing Physical Performance of Military Police Officers

Objective: To analyze the myometrial thickness of rats subjected to creatine (Cr) ingestion. Study design: A total of 14 rats was equally divided into the control group (ConGr) receiving 1 ml potable water and the creatine group (CrGr) subjected to the ingestion of 1.6 g/kg Cr diluted in 1 ml potable water. At the end of 8 weeks, the animals were anesthetized (xylazine and ketamine) and sacrificed, the uteri and ovaries stained with hematoxylin and eosin, the thickness of both the myometrium and the epithelium measured and the follicles counted. Results: Analysis revealed a significant increase in thickness of the myometrium in the CrGr (272.26 ± 66.71μm) contrasted with that from the ConGr (160.76 ± 35.65μm), CrGr > ConGr (p < 0001). Conclusion: Our data suggest that Cr changed myometrial morphology in rats by enhancing myometrial thickness, but its action mechanism in the smooth muscle is still unclear.

Histomorphometric analysis of the effects of creatine on rat myometrium.

After a brief review of the literature on the effects of creatine supplementation on high-intensity intermittent exercise performance, the main aim of this study was to discuss methodological differences between studies which could explain the discrepancies observed in the literature. The effects of creatine supplementation on high-intensity intermittent exercise performance have been investigated in depth. Although the results of much research demonstrates the effi cacy of this supplement, there is just as much evidence that does not support this ergogenic effect. The explanation for this divergence appears to be multifactorial, although it is always linked to methodological characteristics. Study design (crossover or parallel groups), individual variability of muscular creatine content, chronic high meat intake, sample size, exercise protocol characteristics (body weight dependence and time between series), and gender and age all differ between studies and are potentially the variables responsible, to differing extents, for the discrepancies observed in the literature. Studies involving young males, with parallel group design, adequate statistical power, control of the incorporation of creatine into muscles, food intake assessment and intermittent exercise protocols in which performance is independent of body weight and with rest-recovery intervals of 1 to 6 minutes, usually produce positive results. The many methodological factors which can contribute to divergence on the ergogenic effects of creatine should be considered in futures studies, as well as when prescribing creatine supplementation.

EfEitos da suplEmEntação dE CrEatina no ExErCíCio intErmitEntE dE alta intEnsidadE: divErgênCias E rEComEndaçõEs mEtodolÓgiCas EFFECTS OF CREATINE SUPPLEMENTATION ON HIGH-INTENSITY INTERMITTENT EXERCISE: DISCREPANCIES AND METHODOLOGICAL APPRAISALS

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EfEitos da suplEmEntação dE CrEatina no ExErCíCio intErmitEntE dE alta intEnsidadE: divErgênCias E rEComEndaçõEs mEtodolÓgiCas EFFECTS OF CREATINE SUPPLEMENTATION ON HIGH-INTENSITY INTERMITTENT EXERCISE: DISCREPANCIES AND METHODOLOGICAL APPRAISALS