Julio C. Tapia
University of Chile
51 Papers
134 Citations
Julio C. Tapia is an academic researcher from University of Chile. The author has contributed to research in topics: Cancer & Survivin. The author has an hindex of 20, co-authored 44 publications.
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Papers
Casein kinase 2 (CK2) increases survivin expression via enhanced β-catenin–T cell factor/lymphoid enhancer binding factor-dependent transcription
TL;DR: Results suggest that CK2 kinase activity promotes survival by increasing survivin expression via β-catenin–Tcf/Lef-mediated transcription and selective CK2 inhibition or down-regulation in tumors may provide an attractive opportunity for the development of novel cancer therapies.
139
Survivin expression promotes VEGF-induced tumor angiogenesis via PI3K/Akt enhanced β-catenin/Tcf-Lef dependent transcription
Jaime G. Fernandez,Diego A. Rodriguez,Diego A. Rodriguez,Manuel Valenzuela,Claudia Calderon,Ulises Urzúa,David J. Munroe,Carlos Rosas,David Lemus,Natalia Díaz,Mathew C Wright,Lisette Leyton,Julio C. Tapia,Andrew F. G. Quest +13 more
TL;DR: Evidence is provided for the existance of a posititve feedback loop connecting survivin expression in tumor cells to PI3K/Akt enhanced β-catenin-Tcf/Lef-dependent transcription followed by secretion of VEGF and angiogenesis.
Caveolin-1 controls cell proliferation and cell death by suppressing expression of the inhibitor of apoptosis protein survivin.
Vicente A. Torres,Julio C. Tapia,Diego A. Rodriguez,Mario Párraga,Mario Párraga,Pamela Lisboa,Margarita Montoya,Lisette Leyton,Andrew F. G. Quest +8 more
TL;DR: Results suggest that anti-proliferative and pro-apoptotic properties of caveolin-1 may be attributed to reduced survivin expression via a mechanism involving diminished β-catenin-Tcf/Lef-dependent transcription.
E-Cadherin Is Required for Caveolin-1-Mediated Down-Regulation of the Inhibitor of Apoptosis Protein Survivin via Reduced β-Catenin-Tcf/Lef-Dependent Transcription
Vicente A. Torres,Julio C. Tapia,Diego A. Rodriguez,Alvaro Lladser,Cristian Arredondo,Lisette Leyton,Andrew F. G. Quest +6 more
TL;DR: Caveolin-1 and E-cadherin were shown to inhibit the expression of the inhibitor of apoptosis protein survivin via a transcriptional mechanism involving the β-catenin-Tcf/Lef pathway.
123
Neuronal Thy-1 induces astrocyte adhesion by engaging syndecan-4 in a cooperative interaction with αvβ3 integrin that activates PKCα and RhoA
Ana M. Avalos,Alejandra Valdivia,Nicolás Muñoz,Rodrigo Herrera-Molina,Julio C. Tapia,Sergio Lavandero,Mario Chiong,Keith Burridge,Pascal Schneider,Andrew F. G. Quest,Lisette Leyton +10 more
TL;DR: Combined interaction of the astrocyte αvβ3-integrin–syndecan-4 receptor pair with Thy-1, promotes adhesion to the underlying matrix via PKCα- and RhoA-dependent pathways.