Juliette Gray
University of Cambridge
4 Papers
Juliette Gray is an academic researcher from University of Cambridge. The author has contributed to research in topics: Neurotrophic factors & Tropomyosin receptor kinase B. The author has an hindex of 4, co-authored 4 publications.
Chat about Author
Papers
A de novo mutation affecting human TrkB associated with severe obesity and developmental delay
Giles S.H. Yeo,Chiao-Chien Connie Hung,Justin J. Rochford,Julia M. Keogh,Juliette Gray,Shoba Sivaramakrishnan,Stephen O'Rahilly,I. Sadaf Farooqi +7 more
TL;DR: Mutation of NTRK2, which encodes TrkB, seems to result in a unique human syndrome of hyperphagic obesity and the associated impairment in memory, learning and nociception seen in the proband reflects the crucial role of TrkB in the human nervous system.
626
Hyperphagia, Severe Obesity, Impaired Cognitive Function, and Hyperactivity Associated With Functional Loss of One Copy of the Brain-Derived Neurotrophic Factor (BDNF) Gene
Juliette Gray,Giles S.H. Yeo,James J. Cox,Jenny Morton,Anna-Lynne R. Adlam,Julia M. Keogh,Jack A. Yanovski,Areeg El Gharbawy,Joan C. Han,Y. C. Loraine Tung,John R. Hodges,F. Lucy Raymond,Stephen O'Rahilly,I. Sadaf Farooqi +13 more
TL;DR: An 8-year-old girl with hyperphagia and severe obesity, impaired cognitive function, and hyperactivity who harbored a de novo chromosomal inversion is reported, providing direct evidence for the role of the neurotrophin BDNF in human energy homeostasis, as well as in Cognitive function, memory, and behavior.
508
Rapid-Onset Obesity With Hypothalamic Dysfunction, Hypoventilation, and Autonomic Dysregulation Presenting in Childhood
Diego Ize-Ludlow,Juliette Gray,Mark A. Sperling,Elizabeth Berry-Kravis,Jeff M. Milunsky,I. Sadaf Farooqi,Casey M. Rand,Debra E. Weese-Mayer +7 more
TL;DR: Positive PHOX2B sequencing results demonstrate that this entity is distinct from congenital central hypoventilation syndrome, and provides a comprehensive description of the clinical spectrum of rapid-onset obesity with hypothalamic dysfunction, hypventilation, and autonomic dysregulation.
Functional characterization of human NTRK2 mutations identified in patients with severe early-onset obesity
Juliette Gray,Giles S.H. Yeo,Chiao-Chien Connie Hung,Julia M. Keogh,Peter E. Clayton,Kausik Banerjee,A McAulay,Stephen O'Rahilly,I. S. Farooqi +8 more
TL;DR: In this article, a more detailed analysis of the in vitro functional consequences of the mutations identified: I98V, P660L, T821A and Y722C was performed.