Julien Castel
Paris Diderot University
41 Papers
37 Citations
Julien Castel is an academic researcher from Paris Diderot University. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 15, co-authored 27 publications. Previous affiliations of Julien Castel include Centre national de la recherche scientifique.
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Papers
Mitochondrial reactive oxygen species are obligatory signals for glucose-induced insulin secretion.
Corinne Leloup,Cécile Tourrel-Cuzin,Christophe Magnan,Melis Karaca,Julien Castel,Lionel Carneiro,Anne-Laure Colombani,Alain Ktorza,Louis Casteilla,Luc Pénicaud +9 more
TL;DR: It is demonstrated that mROS production is a necessary stimulus for glucose-induced insulin secretion by investigating the mitochondrial origin of ROS (mROS) as the triggering signal.
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Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status
Amandine Everard,Lucie Geurts,Robert Caesar,Matthias Van Hul,Sébastien Matamoros,Thibaut Duparc,Raphael G. P. Denis,Perrine Cochez,Florian Pierard,Julien Castel,Laure B. Bindels,Hubert Plovier,Sylvie Robine,Giulio G. Muccioli,Jean-Christophe Renauld,Laure Dumoutier,Nathalie M. Delzenne,Serge Luquet,Fredrik Bäckhed,Patrice D. Cani +19 more
TL;DR: Inducible intestinal epithelial cell-specific deletion of MyD88 partially protects against diet-induced obesity, diabetes and inflammation and is associated with increased energy expenditure, an improved glucose homeostasis, reduced hepatic steatosis, fat mass and inflammation.
Adipose tissue NAPE-PLD controls fat mass development by altering the browning process and gut microbiota
Lucie Geurts,Amandine Everard,Matthias Van Hul,Ahmed Essaghir,Thibaut Duparc,Sébastien Matamoros,Hubert Plovier,Julien Castel,Raphael G. P. Denis,Marie Bergiers,Céline Druart,Mireille Alhouayek,Nathalie M. Delzenne,Giulio G. Muccioli,Jean-Baptiste Demoulin,Serge Luquet,Patrice D. Cani +16 more
TL;DR: It is reported that Napepld-deleted mice present an altered browning programme and are less responsive to cold-induced browning, highlighting the essential role of NAPE-PLD in regulating energy homeostasis and metabolism in the physiological state.
Physiological and Pharmacological Mechanisms through which the DPP-4 Inhibitor Sitagliptin Regulates Glycemia in Mice
Aurélie Waget,Cendrine Cabou,Myriam Masseboeuf,Pierre Cattan,Mattieu Armanet,Melis Karaca,Julien Castel,Céline Garret,Gaëlle Payros,Adriano Maida,Thierry Sulpice,Jens J. Holst,Daniel J. Drucker,Christophe Magnan,Rémy Burcelin +14 more
TL;DR: It is demonstrated that very low doses of oral sitagliptin improve glucose tolerance and plasma insulin levels with selective reduction of intestinal but not systemic DPP-4 activity.
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Palatability Can Drive Feeding Independent of AgRP Neurons
Raphael G. P. Denis,Aurélie Joly-Amado,E.S. Webber,E.S. Webber,Fanny Langlet,Marie Schaeffer,Stephanie L Padilla,Céline Cansell,Bénédicte Dehouck,Julien Castel,Anne Sophie Delbès,Sarah Martinez,Amélie Lacombe,Claude Rouch,Nadim Kassis,Jean-Alain Fehrentz,Jean Martinez,Pascal Verdié,Thomas S. Hnasko,Richard D. Palmiter,Michael J. Krashes,Michael J. Krashes,Ali D. Güler,Christophe Magnan,Serge Luquet +24 more
TL;DR: It is demonstrated that the feeding response to a fast ghrelin or serotonin receptor agonist relies on AgRP neurons, and neural circuits sensitive to emotion and stress are engaged and modulated by food palatability and dopamine signaling.
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