Julie B. Stimmel
GlaxoSmithKline
35 Papers
445 Citations
Julie B. Stimmel is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Peroxisome proliferator-activated receptor & Nuclear receptor. The author has an hindex of 21, co-authored 34 publications. Previous affiliations of Julie B. Stimmel include Research Triangle Park.
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Papers
Bile Acids: Natural Ligands for an Orphan Nuclear Receptor
Derek J. Parks,Steven G. Blanchard,Randy K. Bledsoe,Gyan Chandra,Thomas G. Consler,Steven A. Kliewer,Julie B. Stimmel,Timothy M. Willson,Ann Marie Zavacki,David D. Moore,Jürgen M. Lehmann +10 more
TL;DR: Results provide evidence for a nuclear bile acid signaling pathway that may regulate cholesterol homeostasis and modulated interaction of FXR with a peptide derived from steroid receptor coactivator 1.
2.2K
Orphan Nuclear Receptors Constitutive Androstane Receptor and Pregnane X Receptor Share Xenobiotic and Steroid Ligands
Linda B. Moore,Derek J. Parks,Stacey A. Jones,Randy K. Bledsoe,Thomas G. Consler,Julie B. Stimmel,Bryan Goodwin,Christopher Liddle,Steven G. Blanchard,Timothy M. Willson,Jon L. Collins,Steven A. Kliewer +11 more
TL;DR: It is demonstrated that several of the compounds that regulate mouse and human CAR, including natural steroids, bind directly to the receptors and suggest that CAR, like PXR, is a steroid receptor that is capable of recognizing structurally diverse compounds.
864
Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARα
H. Eric Xu,Thomas B. Stanley,Valerie G. Montana,Millard H. Lambert,Barry G. Shearer,Jeffery E. Cobb,D.D. McKee,Cristin M. Galardi,Kelli D. Plunket,Robert T. Nolte,Derek J. Parks,John T. Moore,Steven A. Kliewer,Timothy M. Willson,Julie B. Stimmel +14 more
TL;DR: Biochemical analyses and structure-based mutagenesis indicate that this mode of co-repressors to nuclear receptors binding is highly conserved across nuclear receptors.
649
Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662.
Lisa M. Leesnitzer,Derek J. Parks,Randy K. Bledsoe,Jeff E. Cobb,Jon L. Collins,Thomas G. Consler,Roderick G. Davis,Emily A. Hull-Ryde,James M. Lenhard,Lisa G. Patel,Kelli D. Plunket,Jennifer L. Shenk,Julie B. Stimmel,Christina Therapontos,Timothy M. Willson,Steven G. Blanchard +15 more
TL;DR: The selective and irreversible nature of GW9662 treatment, and the observation that activity is maintained in cell culture experiments, suggests that this compound may be a useful tool for elucidation of the role of PPARgamma in biological processes.
576
Patent
Assays for ligands for nuclear receptors
Steven G. Blanchard,Steven A. Kliewer,Jürgen M. Lehmann,Derek J. Parks,Julie B. Stimmel,Timothy M. Willson +5 more
- 22 Dec 1999
TL;DR: In this article, a method for identifying ligands for nuclear receptors, utilizing scintillation proximity and fluorescence resonance energy transfer (FRET), and methods of using identified ligands.
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