Julianne Stack
University of Limerick
13 Papers
44 Citations
Julianne Stack is an academic researcher from University of Limerick. The author has contributed to research in topics: Signal transduction & Signal transducing adaptor protein. The author has an hindex of 10, co-authored 13 publications. Previous affiliations of Julianne Stack include Trinity College, Dublin.
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Papers
The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling
TL;DR: The fifth mammalian TIR adaptor SARM is a negative regulator of Toll-like receptor signaling, and 'knockdown' of endogenous SARM expression by interfering RNA led to enhanced TRIF-dependent cytokine and chemokine induction.
Vaccinia virus protein A46R targets multiple Toll-like–interleukin-1 receptor adaptors and contributes to virulence
Julianne Stack,Ismar R. Haga,Martina Schröder,Nathan W. Bartlett,Geraldine Maloney,Patrick C. Reading,Katherine A. Fitzgerald,Geoffrey L. Smith,Andrew G. Bowie +8 more
TL;DR: The function of the vaccinia virus (VV) protein A46R is defined and it is shown it inhibits intracellular signalling by a range of Toll-like receptors (TLRs) and is functionally distinct from another described VV TLR inhibitor, A52R.
Poxvirus Protein N1L Targets the I-κB Kinase Complex, Inhibits Signaling to NF-κB by the Tumor Necrosis Factor Superfamily of Receptors, and Inhibits NF-κB and IRF3 Signaling by Toll-like Receptors
Gary DiPerna,Julianne Stack,Andrew G. Bowie,Annemarie Boyd,Girish J. Kotwal,Girish J. Kotwal,Zhouning Zhang,Sheila Arvikar,Eicke Latz,Katherine A. Fitzgerald,William L. Marshall,William L. Marshall +11 more
TL;DR: A role is defined for N1L as an immunomodulator of innate immunity by targeting components of NF-κB and IRF3 signaling pathways, which are consistent with the hypothesis that N 1L disrupts signaling to NF-π by Toll/IL-1Rs and TNF superfamily receptors by targeting the IKK complex for inhibition.
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Peptide identification from a Porphyra dioica protein hydrolysate with antioxidant, angiotensin converting enzyme and dipeptidyl peptidase IV inhibitory activities
Maria Cermeño,Julianne Stack,Paul R. Tobin,Martina B. O'Keeffe,Pádraigín A. Harnedy,Dagmar B. Stengel,Richard J. FitzGerald +6 more
TL;DR: The results indicate that P. dioica-derived peptides may have potential applications as health enhancing ingredients in addition to their current uses as bioactivity enhancing ingredients.
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Poxviral Protein A46 Antagonizes Toll-like Receptor 4 Signaling by Targeting BB Loop Motifs in Toll-IL-1 Receptor Adaptor Proteins to Disrupt Receptor:Adaptor Interactions
Julianne Stack,Andrew G. Bowie +1 more
TL;DR: This study provides the molecular basis for pathogen subversion of TLR4 signaling and clarifies the importance of TIR motif BB loops, which have been selected for viral antagonism, in the formation of theTLR4 complex.
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