Julian Parkhill
University of Cambridge
788 Papers
3K Citations
Julian Parkhill is an academic researcher from University of Cambridge. The author has contributed to research in topics: Biology & Genome. The author has an hindex of 149, co-authored 759 publications. Previous affiliations of Julian Parkhill include Wellcome Trust Sanger Institute & Wellcome Trust Centre for Human Genetics.
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Papers
Large scale genomic analysis shows no evidence for repeated pathogen adaptation during the invasive phase of bacterial meningitis in humans
John A. Lees,Philip H. C. Kremer,Ana Sousa Manso,Nicholas J. Croucher,Bart Ferwerda,Mercedes Valls Serón,Marco R. Oggioni,Julian Parkhill,Matthijs C. Brouwer,Arie van der Ende,Diederik van de Beek,Stephen D. Bentley +11 more
TL;DR: It is found that evolution after invasion in bacterial meningitis is not a major contribution to disease pathogenesis, and variation discovered from nasopharyngeal isolates suggest that larger studies comparing carriage and invasion may help determine the likely mechanisms of invasiveness.
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Correction: Dynamics and impact of homologous recombination on the evolution of Legionella pneumophila.
Sophia David,Leonor Sánchez-Busó,Simon R. Harris,Pekka Marttinen,Christophe Rusniok,Carmen Buchrieser,Timothy G. Harrison,Julian Parkhill +7 more
TL;DR: This research presents a novel probabilistic approach to estimating the response of the immune system to laser-spot assisted, 3D image analysis of central nervous system injury.
Are commercial providers a viable option for clinical bacterial sequencing
Kathy E. Raven,Beth Blane,Carol Churcher,Julian Parkhill,Sharon J. Peacock,Sharon J. Peacock,Sharon J. Peacock +6 more
- 05 Apr 2018
TL;DR: The results indicate that external providers returned highly accurate genome data, but that improvements are required in turnaround time to make this a viable option for use in clinical practice.
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The Genome Sequences of Three Paraburkholderia sp. Strains Isolated from Wood-Decay Fungi Reveal Them as Novel Species with Antimicrobial Biosynthetic Potential.
Gordon Webster,Alex J. Mullins,Aimee S. Bettridge,Cerith Jones,Edward Cunningham-Oakes,Thomas R. Connor,Julian Parkhill,Eshwar Mahenthiralingam +7 more
- 22 Aug 2019
TL;DR: Three strains of fungus-associated Burkholderiales bacteria with antagonistic activity against Gram-negative plant pathogens were genome sequenced to investigate their taxonomic placement and potential for antimicrobial specialized metabolite production.
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Annotation of microbial genomes
TL;DR: It is explained that annotation of genomic information is an extremely powerful tool for the understanding of biology, but can be fraught with problems and pitfalls, and the annotator must always be aware of potential problems.
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