Julian Parkhill
University of Cambridge
788 Papers
3K Citations
Julian Parkhill is an academic researcher from University of Cambridge. The author has contributed to research in topics: Biology & Genome. The author has an hindex of 149, co-authored 759 publications. Previous affiliations of Julian Parkhill include Wellcome Trust Sanger Institute & Wellcome Trust Centre for Human Genetics.
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Papers
Mutations in the MAB_2299c TetR Regulator Confer Cross-Resistance to Clofazimine and Bedaquiline in Mycobacterium abscessus.
Matthias Richard,Ana Victoria Gutiérrez,Ana Victoria Gutiérrez,Albertus Viljoen,Daniela Rodriguez-Rincon,Françoise Roquet-Banères,Mickaël Blaise,Isobel Everall,Julian Parkhill,R. Andres Floto,Laurent Kremer,Laurent Kremer +11 more
TL;DR: The results expand knowledge with respect to the regulatory mechanisms of the MmpL family of proteins and a novel mechanism of drug resistance in this difficult-to-treat respiratory mycobacterial pathogen.
Reagent contamination can critically impact sequence-based microbiome analyses
Susannah J. Salter,Michael J. Cox,Elena M. Turek,Szymon T. Calus,William O.C.M. Cookson,Miriam F. Moffatt,Paul Turner,Julian Parkhill,Nicholas J. Loman,Alan W. Walker +9 more
TL;DR: It is demonstrated that contaminating DNA is ubiquitous in commonly used DNA extraction kits, varies greatly in composition between different kits and kit batches, and that this contamination critically impacts results obtained from samples containing a low microbial biomass.
Genome specialization and decay of the strangles pathogen, Streptococcus equi, is driven by persistent infection
Simon R. Harris,Carl Robinson,Karen F. Steward,K. Webb,Romain Paillot,Julian Parkhill,Matthew T. G. Holden,Matthew T. G. Holden,Andrew S. Waller +8 more
TL;DR: The global population structure of S. equi is defined and a population replacement in the late 19th or early 20th Century is revealed, revealing a dynamic genome that continues to mutate and decay, but also to amplify and acquire genes despite the organism having lost its natural competence and become host-restricted.
Phylogenomic exploration of the relationships between strains of Mycobacterium avium subspecies paratuberculosis
Josephine M. Bryant,Josephine M. Bryant,Virginie C. Thibault,David Ge Smith,Joyce McLuckie,Ian Heron,Iker A. Sevilla,Franck Biet,Simon R. Harris,Duncan J. Maskell,Stephen D. Bentley,Julian Parkhill,Karen Stevenson +12 more
TL;DR: The first whole genome sequencing of 141 global Map isolates that encompass the main molecular strain types currently reported clarifies the phylogenetic relationships between the previously described Map strain groups, and highlights the limitations of current genotyping techniques.
Construction and characterization of a mercury-independent MerR activator (MerRAC): transcriptional activation in the absence of Hg(II) is accompanied by DNA distortion
TL;DR: The degree of activation caused by these mutants directly correlates with the degree of DNA distortion as measured by the hypersensitivity of MerR‐DNA complexes to the nuclease Cu‐5‐phenyl‐o‐phenanthroline.