Julian Lee
National University of Singapore
7 Papers
Julian Lee is an academic researcher from National University of Singapore. The author has contributed to research in topics: Cancer & Gene expression profiling. The author has an hindex of 7, co-authored 7 publications.
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Papers
Oncogenic Pathway Combinations Predict Clinical Prognosis in Gastric Cancer
Chia Huey Ooi,Tatiana Ivanova,Jeanie Wu,Minghui Lee,Iain Beehuat Tan,Jiong Tao,Lindsay C. Ward,Jun Hao Koo,Veena Gopalakrishnan,Yansong Zhu,Lai Ling Cheng,Julian Lee,Sun Young Rha,Hyun Cheol Chung,Kumaresan Ganesan,Jimmy Bok Yan So,Khee Chee Soo,Dennis T. H. Lim,Weng Hoong Chan,Wai-Keong Wong,David D.L. Bowtell,Khay Guan Yeoh,Heike Grabsch,Alex Boussioutas,Alex Boussioutas,Patrick Tan +25 more
TL;DR: Using gene expression signatures, this paper identified major oncogenic pathways in gastric cancer (GC) with significant relationships to patient survival, and devised an in-silico strategy to map patterns of pathway activation in 301 primary gastric cancers, the second highest cause of global cancer mortality.
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Oncogenic Pathway Combinations Predict Clinical Prognosis in Gastric Cancer
Chia Huey Ooi,Tatiana Ivanova,Jeanie Wu,Minghui Lee,Iain Beehuat Tan,Jiong Tao,Lindsay C. Ward,Jun Hao Koo,Veena Gopalakrishnan,Yansong Zhu,Lai Ling Cheng,Julian Lee,Sun Young Rha,Hyun Cheol Chung,Kumaresan Ganesan,Jimmy Bok Yan So,Khee Chee Soo,Dennis T. H. Lim,Weng Hoong Chan,Wai-Keong Wong,David D.L. Bowtell,Khay Guan Yeoh,Heike Grabsch,Alex Boussioutas,Alex Boussioutas,Patrick Tan +25 more
- 01 Oct 2009
TL;DR: Using gene expression signatures, an in silico strategy to map patterns of oncogenic pathway activation in 301 primary gastric cancers showed reproducible and significant survival differences in multiple cohorts, suggesting that pathway interactions may play an important role in influencing disease behavior.
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Genomic Loss of miR-486 Regulates Tumor Progression and the OLFM4 Antiapoptotic Factor in Gastric Cancer
Hue Kian Oh,Angie Lay Keng Tan,Kakoli Das,Chia Huey Ooi,Niantao Deng,Iain Beehuat Tan,Emmanuel Beillard,Julian Lee,Kalpana Ramnarayanan,Sun Young Rha,Nallasivam Palanisamy,P. Mathijs Voorhoeve,Patrick Tan +12 more
TL;DR: miR-486 may function as a novel tumor-suppressor miRNA in GC, and its antioncogenic activity may involve the direct targeting and inhibition of OLFM4.
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Comprehensive genomic meta-analysis identifies intra-tumoural stroma as a predictor of survival in patients with gastric cancer
Yonghui Wu,Heike Grabsch,Tatiana Ivanova,Iain Beehuat Tan,Jacinta Murray,Chia Huey Ooi,A Wright,Nicholas P. West,Gordon G A Hutchins,Jeanie Wu,Minghui Lee,Julian Lee,Jun Hao Koo,Khay Guan Yeoh,Nicole C.T. van Grieken,Bauke Ylstra,Sun Young Rha,Jaffer A. Ajani,Jae Ho Cheong,Sung Hoon Noh,Kiat Hon Lim,Alex Boussioutas,Alex Boussioutas,Ju Seog Lee,Patrick Tan,Patrick Tan +25 more
TL;DR: Stromal gene expression predicts GC patient survival in multiple independent cohorts, and may be closely related to the intra-tumoural stroma proportion, a specific morphological GC phenotype, which suggest that therapeutic approaches targeting the GC stroma may merit evaluation.
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Integrated epigenomics identifies BMP4 as a modulator of cisplatin sensitivity in gastric cancer
Tatiana Ivanova,Hermioni Zouridis,Yonghui Wu,Lai Ling Cheng,Iain Beehuat Tan,Veena Gopalakrishnan,Chia Huey Ooi,Julian Lee,Luo Qin,Jeanie Wu,Minghui Lee,Sun Young Rha,Dan Huang,Natalia Liem,Khay Guan Yeoh,Wei Peng Yong,Bin Tean Teh,Patrick Tan,Patrick Tan +18 more
TL;DR: Epigenomic analysis identified bone morphogenetic protein 4 (BMP4) as an epigenetically regulated gene highly expressed in cisplatin-resistant lines, and functional assays confirmed that BMP4 is necessary and sufficient for the expression of several prooncogenic traits, likely mediated through stimulation of the epithelial-mesenchymal transition.
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