Julian A. Hiscox
University of Liverpool
196 Papers
763 Citations
Julian A. Hiscox is an academic researcher from University of Liverpool. The author has contributed to research in topics: Virus & Biology. The author has an hindex of 47, co-authored 166 publications. Previous affiliations of Julian A. Hiscox include University of Cambridge & University of Reading.
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Papers
SARS-CoV-2 minor variant genomes at the start of the pandemic contained markers of VoCs
Xiaofeng Dong,Julian A. Hiscox +1 more
TL;DR: SARS-CoV-2 emerged through limited zoonotic spillovers and was predicted to have constrained sequence diversity, but there were minor variant genomes present in each sample, which encompassed synonymous and non-synonymous changes.
Myosin Heavy Chain 9 is Involved in Murine Gammaherpesvirus 68 Infection and as a Drug Target for Antiviral Infection
Ximeng Han,Jordan J. Clark,Parul Sharma,Eleanor G. Bentley,Anja Kipar,Mohammed Alsayer,Xiaolei Ren,A. Robinson,Chloe Bramwell,Adam Kirby,Sondus ALAidarous,Yang Mu,Yani Sun,Julian A. Hiscox,En-Min Zhou,James P. Stewart,Qin Zhao +16 more
Control of TGEV mRNA Transcription
TL;DR: A virus specific mRNA isolation method was developed to measure the relative amounts of mRNAs synthesised during an infection of LLC-PK1 cells with TGEV (strain FS772/70) and found that the relative quantity of each mRNA can be determined and correlated with the variation in size of the leader binding site.
TREM-1 activation is a key regulator in driving severe pathogenesis of enterovirus 71 infection
Siti Naqiah Amrun,Jeslin J. L. Tan,Natasha Y. Rickett,Jonathan A. Cox,Jonathan A. Cox,Bernett Lee,Michael J. Griffiths,Tom Solomon,Tom Solomon,David Perera,Mong How Ooi,Mong How Ooi,Julian A. Hiscox,Julian A. Hiscox,Lisa F. P. Ng +14 more
TL;DR: Mechanistically, this is the first report describing the transcriptome profiles during EV71 infections in primary human cells, and the involvement of TREM-1 in the severe disease pathogenesis, thus providing new insights for future treatment targets.
The interaction of animal cytoplasmic RNA viruses with the nucleus to facilitate replication.
TL;DR: A number of positive and negative strand RNA viruses whose primary site of replication is the cytoplasm use the nucleus and/or nuclear components in order to facilitate their replicative processes and alter host cell function.