Julian A. Hiscox
University of Liverpool
196 Papers
763 Citations
Julian A. Hiscox is an academic researcher from University of Liverpool. The author has contributed to research in topics: Virus & Biology. The author has an hindex of 47, co-authored 166 publications. Previous affiliations of Julian A. Hiscox include University of Cambridge & University of Reading.
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Papers
Dose-Dependent Response to Infection with Ebola Virus in the Ferret Model and Evidence of Viral Evolution in the Eye.
Robert J. Watson,Julia A. Tree,Susan A. Fotheringham,Yper Hall,Xiaofeng Dong,Kimberley Steeds,Jade Gouriet,Francisco J. Salguero,Christopher Burton,James Pitman,Linda Easterbrook,Kevin Richards,Jane Burton,Kevin R. Bewley,Christine Bruce,Julian A. Hiscox,Julian A. Hiscox,Miles W. Carroll,Miles W. Carroll,Simon G. P. Funnell +19 more
TL;DR: In this paper, the authors used the ferret as a model for EBOV infection, reproducing disease and lethality observed in humans, and found that the virus has remained in the region for at least 5 years and is likely to have been maintained in humans.
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Anti-idiotypic antibodies reduce efficacy of the attenuated vaccine against highly pathogenic PRRSV challenge.
Ying Yu,Ying Yu,Xuehui Cai,Gang Wang,Ning Kong,Yonggang Liu,Yihong Xiao,Chong Zhang,Yang Mu,Shuqi Xiao,Qin Zhao,Chengbao Wang,Gaiping Zhang,Gaiping Zhang,Julian A. Hiscox,En-Min Zhou +15 more
TL;DR: When anti-GP5 Ab2s are present, the use of attenuated PRRSV vaccine CH-1R against HP-PRRSV infection is not recommended, as it can result in poor health status with pneumonia and thymus atrophy.
Structural Characterization of Non-structural Protein 9 Complexed With Specific Nanobody Pinpoints Two Important Residues Involved in Porcine Reproductive and Respiratory Syndrome Virus Replication.
Yan Wang,Rui Li,Songlin Qiao,Jiaxi Wang,Hongliang Liu,Zhijun Li,Hongfang Ma,Lei Yang,Haiyu Ruan,Maoyang Weng,Julian A. Hiscox,James P. Stewart,Yuchen Nan,Gaiping Zhang,En-Min Zhou +14 more
TL;DR: Structural analysis of the Nsp9-Nb6 complex revealed novel amino acid interactions involved in viral RNA replication that will be useful for guiding development of structure-based anti-PRRSV agents.
Different NF-κB activation characteristics of human respiratory syncytial virus subgroups A and B.
TL;DR: In this article, the authors performed a quantitative and comparative analysis of NF-κB activation in response to infection of both continuous and primary cell cultures with HRSV subgroup A and B isolates.
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Viperin Poisons Viral Replication
TL;DR: It is discovered that the ISG viperin inhibits virus replication by generating the ribonucleotide ddhCTP, which interferes with RNA synthesis, thus offering insights into drug design.
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