Julia Specks
6 Papers
127 Citations
Julia Specks is an academic researcher. The author has contributed to research in topics: Mutant & DNA damage. The author has an hindex of 5, co-authored 6 publications.
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Papers
An extra allele of Chk1 limits oncogene-induced replicative stress and promotes transformation
Andrés J. López-Contreras,Paula Gutierrez-Martinez,Julia Specks,Sara Rodrigo-Perez,Oscar Fernandez-Capetillo +4 more
TL;DR: Protection from replicative stress conferred by Chk1 promotes transformation and reduces the likelihood of cell death and promotes transformation in response to infectious disease.
124
Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice
Andrés J. López-Contreras,Julia Specks,Jacqueline H. Barlow,Chiara Ambrogio,Claus Desler,Svante Vikingsson,Sara Rodrigo-Perez,Henrik Gréen,Lene Juel Rasmussen,Matilde Murga,André Nussenzweig,Oscar Fernandez-Capetillo +11 more
TL;DR: This study reveals the first genetic condition in mammals that reduces fragile site expression and alleviates the severity of a progeroid disease by increasing RNR activity.
A Single Conserved Residue Mediates Binding of the Ribonucleotide Reductase Catalytic Subunit RRM1 to RRM2 and Is Essential for Mouse Development
TL;DR: It is revealed that binding of RRM1 to RRM2 is essential for mammalian cells and the first loss-of-function model of the RNR complex for genetic studies is provided.
10
USP7 couples DNA replication termination to mitotic entry.
Antonio Galarreta,Emilio Lecona,Pablo Valledor,Patricia Ubieto,Vanesa Lafarga,Julia Specks,Oscar Fernandez-Capetillo +6 more
TL;DR: This work reveals that USP7 inhibition leads to the ubiquitination of MCM7, a hallmark of DNA replication termination, and provides evidence to the concept that DNA replicationtermination is coupled to the activation of the mitotic program.
USP7 is a SUMO deubiquitinase essential for DNA replication
Emilio Lecona,Sara Rodriguez-Acebes,Julia Specks,Andrés J. López-Contreras,Isabel Ruppen,Matilde Murga,Javier Muñoz,Juan Méndez,Oscar Fernandez-Capetillo +8 more
TL;DR: This work identifies USP7 as a replisome-enriched SUMO deubiquitinase that is essential for DNA replication and provides a model explaining the differential accumulation of SUMO and Ub at replication forks and identifies an essential role ofUSP7 in DNA replication that should be considered in the development of USP6 inhibitors as anticancer agents.