Julia Lier
Leipzig University
11 Papers
Julia Lier is an academic researcher from Leipzig University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 3, co-authored 5 publications.
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Papers
Beyond Activation: Characterizing Microglial Functional Phenotypes.
TL;DR: A review of commonly used microglial markers and their fluctuations in expression in health and disease, with a focus on IBA1 low/negative microglia, which can be found in individuals with liver disease is presented in this paper.
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Microglial activation occurs late during preclinical Alzheimer's disease
Wolfgang J. Streit,Heiko Braak,Kelly Del Tredici,Judith Leyh,Julia Lier,Habibeh Khoshbouei,Christian Eisenlöffel,Wolf Müller,Ingo Bechmann +8 more
TL;DR: The study suggests that the role of microglia in AD pathogenesis entails primarily the attempted removal of potentially toxic, extracellular material.
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GFAP positivity in neurons following traumatic brain injuries.
Johann Zwirner,Julia Lier,Heike Franke,Niels Hammer,Niels Hammer,Jakob Matschke,Florian Trautz,Rexon Tse,Benjamin Ondruschka +8 more
TL;DR: In this article, cerebral and cerebellar tissues of 52 TBI fatalities and 17 controls were screened for immunopositivity for GFAP in neurons by means of immunohistochemistry and immunofluorescence.
Fast microglial activation after severe traumatic brain injuries.
TL;DR: More studies focusing on cadaveric samples need to follow to thoroughly define the mechanisms leading to cell destruction and eventually evaluate their forensic value, as well as show localization-depending effects on microglial morphology causing localized dystrophy and adjacent activation.
Neuropsychiatric phenotype of post COVID-19 syndrome in non-hospitalized patients
Julia Lier,Kristin Stoll,Hellmuth Obrig,P. Baum,Lea Deterding,Nora Bernsdorff,Franz Hermsdorf,Ines Kunis,Andrea Bräsecke,S. Herzig,Matthias L. Schroeter,Angelika Thöne-Otto,Steffi G. Riedel-Heller,Ulrich Laufs,Hubert Wirtz,Joseph Classen,Dorothee Saur +16 more
TL;DR: A phenotype of PCS dominated by symptoms of fatigue, somatisation and depression is delineated, which warrants a systematic evaluation of psychosocial side effects of the pandemic itself and psychiatric comorbidities on the long-term outcome of patients with SARS-CoV-2 infection.